U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mvk mevalonate kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81727, updated on 22-Sep-2022

Summary

Official Symbol
Mvkprovided by RGD
Official Full Name
mevalonate kinaseprovided by RGD
Primary source
RGD:621295
See related
Ensembl:ENSRNOG00000049604 AllianceGenome:RGD:621295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MK; Lrbp
Summary
Enables several functions, including ATP binding activity; magnesium ion binding activity; and mevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and negative regulation of translation. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 64.6), Liver (RPKM 63.9) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mvk in Genome Data Viewer
Location:
12q16
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42141391..42158858, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47904266..47920457, complement)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene uncharacterized LOC103691433 Neighboring gene metabolism of cobalamin associated B Neighboring gene ubiquitin protein ligase E3B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mevalonate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mevalonate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mevalonate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in isoprenoid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in isoprenoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in isoprenoid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cholesterol biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in sterol metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mevalonate kinase
Names
LHR mRNA binding protein
NP_112325.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393702.1NP_001380631.1  mevalonate kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000229
    Conserved Domains (1) summary
    cl40731
    Location:10376
    PLN02677; mevalonate kinase
  2. NM_031063.2NP_112325.1  mevalonate kinase isoform 1

    See identical proteins and their annotated locations for NP_112325.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000229
    UniProtKB/Swiss-Prot
    P17256
    Related
    ENSRNOP00000077122.1, ENSRNOT00000097267.1
    Conserved Domains (1) summary
    cl40731
    Location:10377
    PLN02677; mevalonate kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    42141391..42158858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)