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Mvk mevalonate kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81727, updated on 3-Jun-2018
Official Symbol
Mvkprovided by RGD
Official Full Name
mevalonate kinaseprovided by RGD
Primary source
RGD:621295
See related
Ensembl:ENSRNOG00000049604
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrbp
Summary
kinase that catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate; involved in the cholesterol biosynthetic pathway [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Brain (RPKM 64.6), Liver (RPKM 63.9) and 9 other tissues See more
Orthologs
See Mvk in Genome Data Viewer
Location:
12q16
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47904266..47920457, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (49695252..49711443, complement)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547205 Neighboring gene uncharacterized LOC103691433 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblB type Neighboring gene ubiquitin protein ligase E3B

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
mevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mevalonate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
mevalonate kinase activity IEA
Inferred from Electronic Annotation
more info
 
mevalonate kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isopentenyl diphosphate biosynthetic process, mevalonate pathway IDA
Inferred from Direct Assay
more info
PubMed 
isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 
isoprenoid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
isoprenoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
isoprenoid metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cholesterol biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
NOT peroxisome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
mevalonate kinase
Names
LHR mRNA binding protein
MK
NP_112325.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031063.1NP_112325.1  mevalonate kinase

    See identical proteins and their annotated locations for NP_112325.1

    Status: PROVISIONAL

    Source sequence(s)
    M29472
    UniProtKB/Swiss-Prot
    P17256
    Related
    ENSRNOP00000064795.1, ENSRNOT00000073774.2
    Conserved Domains (3) summary
    PLN02677
    Location:10377
    PLN02677; mevalonate kinase
    pfam00288
    Location:130212
    GHMP_kinases_N; GHMP kinases N terminal domain
    pfam10509
    Location:343
    GalKase_gal_bdg; Galactokinase galactose-binding signature

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    47904266..47920457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    43753220..43770539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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