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CLV3 CLAVATA3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817267, updated on 18-Nov-2018

Summary

Gene symbol
CLV3
Gene description
CLAVATA3
Primary source
Araport:AT2G27250
Locus tag
AT2G27250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtCLV3; CLAVATA3; F12K2.17; F12K2_17
Summary
One of the three CLAVATA genes controlling the size of the shoot apical meristem (SAM) in Arabidopsis. Belongs to a large gene family called CLE for CLAVATA3/ESR-related. Encodes a stem cell-specific protein CLV3 presumed to be a precursor of a secreted peptide hormone. The deduced ORF encodes a 96-amino acid protein with an 18-amino acid N-terminal signal peptide. The functional form of CLV3 (MCLV3) was first reported to be a posttranscriptionally modified 12-amino acid peptide, in which two of the three prolines were modified to hydroxyproline (Ito et al., Science 2006, 313:842; Kondo et al., Science 2006, 313:845). Ohyama et al. (2009) later reported that the active mature CLV3 is a 13-amino-acid arabinosylated glycopeptide (Nature Chemical Biology, 5:578). CLV3 binds the ectodomain of the CLAVATA1 (CLV1) receptor-kinase. Regulates shoot and floral meristem development. Required for CLAVATA1 receptor-like kinase assembly into a signaling complex that includes KAPP and a Rho-related protein. It restricts its own domain of expression, the central zone (CZ) of the shoot apical meristem (SAM), by preventing differentiation of peripheral zone cells, which surround the CZ, into CZ cells and restricts overall SAM size by a separate, long-range effect on cell division rate. CLE domain of CLV3 is sufficient for function. Results obtained from whole seedlings challenge the concept that the immune receptor FLS2 perceives the meristematic regulatory peptide CLV3p in mesophyll, seedlings, and SAM cells and that CLV3p contributes to SAM immunity against bacterial infection (PMID:22923673).

Genomic context

See CLV3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (11664978..11665797, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene transcription factor-like protein Neighboring gene aluminum activated malate transporter family protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene miscRNA

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

NM_001124926.2
NM_128283.2
NM_201812.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
kinase activator activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 
receptor serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
apoplast IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISM
Inferred from Sequence Model
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISM
Inferred from Sequence Model
more info
 

General protein information

Preferred Names
CLAVATA3
NP_001118398.1
  • CLAVATA3 (CLV3); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_565641.2
  • CLAVATA3 (CLV3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_973541.1
  • CLAVATA3 (CLV3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11664978..11665797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001124926.2NP_001118398.1  CLAVATA3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118398.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XF04
  2. NM_201812.1NP_973541.1  CLAVATA3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973541.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XF04
  3. NM_128283.2NP_565641.2  CLAVATA3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565641.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3E6N8
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