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Ager advanced glycosylation end product-specific receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 81722, updated on 2-Oct-2018

Summary

Official Symbol
Agerprovided by RGD
Official Full Name
advanced glycosylation end product-specific receptorprovided by RGD
Primary source
RGD:69258
See related
Ensembl:ENSRNOG00000000439 Vega:OTTRNOG00000001708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RAGE
Summary
cell surface receptor for various molecules, including the amyloidogenic form of serum amyloid A [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 4393.2) See more
Orthologs

Genomic context

See Ager in Genome Data Viewer
Location:
20p12
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4363152..4366079)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (6442508..6445435)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19 Neighboring gene G-protein signaling modulator 3 Neighboring gene PBX homeobox 2 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene ring finger protein 5 Neighboring gene EGF-like-domain, multiple 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
S100 protein binding IEA
Inferred from Electronic Annotation
more info
 
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
advanced glycation end-product binding ISO
Inferred from Sequence Orthology
more info
 
advanced glycation end-product receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
high mobility group box 1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
astrocyte development ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
glucose mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
glucose mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
glycoprotein metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
lung development IEP
Inferred from Expression Pattern
more info
PubMed 
modulation of age-related behavioral decline IEA
Inferred from Electronic Annotation
more info
 
modulation of age-related behavioral decline ISO
Inferred from Sequence Orthology
more info
 
negative regulation of advanced glycation end-product receptor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of connective tissue replacement involved in inflammatory response wound healing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of connective tissue replacement involved in inflammatory response wound healing ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of astrocyte activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotactic protein-1 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of potassium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of CD4-positive, alpha-beta T cell activation IEA
Inferred from Electronic Annotation
more info
 
regulation of CD4-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of spontaneous synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
regulation of spontaneous synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
response to fructose IEP
Inferred from Expression Pattern
more info
PubMed 
response to genistein IEP
Inferred from Expression Pattern
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to methylglyoxal IEP
Inferred from Expression Pattern
more info
PubMed 
response to selenite ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
transdifferentiation IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
fibrillar center IEA
Inferred from Electronic Annotation
more info
 
fibrillar center ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
advanced glycosylation end product-specific receptor
Names
advanced glycosylation end product-specific receptor variant 2
advanced glycosylation end product-specific receptor variant 3
advanced glycosylation end product-specific receptor variant 4
advanced glycosylation end product-specific receptor variant 5
receptor for advanced glycosylation end products

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053336.2NP_445788.2  advanced glycosylation end product-specific receptor precursor

    See identical proteins and their annotated locations for NP_445788.2

    Status: VALIDATED

    Source sequence(s)
    BC084697, BX883044, CR475487
    UniProtKB/TrEMBL
    Q6MG86
    Related
    ENSRNOP00000000508.1, OTTRNOP00000001614, ENSRNOT00000000508.4, OTTRNOT00000002740
    Conserved Domains (4) summary
    smart00408
    Location:249304
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:242318
    IG_like; Immunoglobulin like
    pfam08205
    Location:123216
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:25111
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    4363152..4366079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256025.2XP_006256087.1  advanced glycosylation end product-specific receptor isoform X1

    See identical proteins and their annotated locations for XP_006256087.1

    UniProtKB/TrEMBL
    A0A0G2K218
    Related
    ENSRNOP00000072071.1, OTTRNOP00000001615, ENSRNOT00000084841.1, OTTRNOT00000002744
    Conserved Domains (4) summary
    smart00408
    Location:249304
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:242318
    IG_like; Immunoglobulin like
    pfam08205
    Location:123216
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:25111
    Ig; Immunoglobulin domain

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    3879126..3882053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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