PYL2 PYR1-like 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PYL2
Official Full Name: PYR1-like 2
Primary source: TAIR:AT2G26040
Locus tag: AT2G26040
See related: Araport:AT2G26040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: PYR1-like 2; RCAR14; regulatory components of ABA receptor 14; T19L18.15; T19L18_15
Summary: Encodes a member of the PYR (pyrabactin resistance)/PYL(PYR1-like)/RCAR (regulatory components of ABA receptor) family proteins with 14 members. PYR/PYL/RCAR family proteins function as abscisic acid sensors. Mediate ABA-dependent regulation of protein phosphatase 2Cs ABI1 and ABI2.
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Genomic context

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See PYL2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (11094258..11095542, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular basis of the activation and dissociation of dimeric PYL2 receptor in abscisic acid signaling.
Title: Molecular basis of the activation and dissociation of dimeric PYL2 receptor in abscisic acid signaling.
Of the six members of the PYR/PYL/RCAR family expressed in guard cells, PYL2 is sufficient for guard cell abscisc acid-induced responses, whereas in the responses to CO2, PYL4 and PYL5 are essential.
Title: The role of Arabidopsis ABA receptors from the PYR/PYL/RCAR family in stomatal acclimation and closure signal integration.
Molecular dynamics simulations have been applied to two different PYL2-HAB1 complex heterodimer systems representing normal and magnesium deficient conditions. The heterodimer conformation and stability were delineated at high temperatures mimicking heat stress. Results showed that the thermostability of the heat stress response heterodimer was significantly dependent on the magnesium.
Title: Thermostability of the PYL-PP2C Heterodimer Is Dependent on Magnesium: In Silico Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants.
These findings confirm that the subfamily III plays a key role in ABA-mediated developmental processes and, more importantly, is involved in drought tolerance in the ABA-dependent pathway.
Title: ABA Receptor Subfamily III Enhances Abscisic Acid Sensitivity and Improves the Drought Tolerance of Arabidopsis.
Abscisic acid receptor PYL2 deletion changes the phosphorylation pattern of SnRK2 in response to abscisic acid signaling.
Title: Rapid Phosphoproteomic Effects of Abscisic Acid (ABA) on Wild-Type and ABA Receptor-Deficient A. thaliana Mutants.
study reports a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors; structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation
Title: Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
Subtle changes in the binding pockets of PYR/PYL proteins control ligand orientation inside the pocket, and this is sufficient to explain whether pyrabactin acts as an effective receptor agonist. [PYL2]
Title: Structural basis for selective activation of ABA receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables abscisic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in abscisic acid-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in abscisic acid-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: PYR1-like 2

NP_180174.1

PYR1-like 2 (PYL2); CONTAINS InterPro DOMAIN/s: Polyketide cyclase/dehydrase (InterPro:IPR019587); BEST Arabidopsis thaliana protein match is: PYR1-like 3 (TAIR:AT1G73000.1); Has 445 Blast hits to 441 proteins in 38 species: Archae - 0; Bacteria - 5; Metazoa - 0; Fungi - 0; Plants - 439; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11094258..11095542 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128163.2 → NP_180174.1 PYR1-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180174.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80992

UniProtKB/TrEMBL

A0A654EW91

Conserved Domains (1) summary

cd07821
Location:35 → 177

PYR_PYL_RCAR_like; Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins