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RPA2 replicon protein A2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816985, updated on 3-Oct-2024
Official Symbol
RPA2
Official Full Name
replicon protein A2
Primary source
TAIR:AT2G24490
Locus tag
AT2G24490
See related
Araport:AT2G24490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRPA2; ATRPA32A; replicon protein A2; ROR1; RPA32A; SUPPRESSOR OF ROS1; T28I24.22; T28I24_22
Summary
Encodes a component of Replication Protein A. Component of transcriptional gene silencing which does not affect endogenous small RNA accumulation nor DNA methylation. Localized in the nucleus. Involved in DNA repair. Interacts physically with ROS1.
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See RPA2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Sequence:
Chromosome: 2; NC_003071.7 (10397377..10400802, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene filament-like protein (DUF869) Neighboring gene Zinc finger, C3HC4 type (RING finger) family protein Neighboring gene Zinc finger protein 622 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRL1 interacts with and stabilizes RPA2A to regulate carbon deprivation-induced senescence in Arabidopsis.
    Title: PRL1 interacts with and stabilizes RPA2A to regulate carbon deprivation-induced senescence in Arabidopsis.
  2. study provides a mechanistic understanding of the CDK-mediated phosphorylation of RPA in the precise control of cell cycle and DNA repair in plants.
    Title: A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division.
  3. Results suggest important roles for ROR1/RPA2A in epigenetic gene silencing and in the regulation of plant development.
    Title: ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis.
  4. Arabidopsis RPA2 is a genetic link between transcriptional gene silencing, DNA repair, and DNA replication.
    Title: Arabidopsis RPA2: a genetic link among transcriptional gene silencing, DNA repair, and DNA replication.
  5. At2g24490 is the RPA2 gene, which plays an essential role in the maintenance of transcriptional gene silencing at specific loci in a DNA-methylation-independent manner.
    Title: Mutations in a conserved replication protein suppress transcriptional gene silencing in a DNA-methylation-independent manner in Arabidopsis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

NM_001124904.1
NM_128010.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
Preferred Names
replicon protein A2
NP_001118376.1
  • replicon protein A2 (RPA2); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Replication protein A, subunit RPA32 (InterPro:IPR014646), Replication protein A, C-terminal (InterPro:IPR014892), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365); BEST Arabidopsis thaliana protein match is: Replication protein A, subunit RPA32 (TAIR:AT3G02920.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_565571.1
  • replicon protein A2 (RPA2); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Replication protein A, subunit RPA32 (InterPro:IPR014646), Replication protein A, C-terminal (InterPro:IPR014892), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365); BEST Arabidopsis thaliana protein match is: Replication protein A, subunit RPA32 (TAIR:AT3G02920.1); Has 524 Blast hits to 524 proteins in 181 species: Archae - 0; Bacteria - 0; Metazoa - 245; Fungi - 127; Plants - 108; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    10397377..10400802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001124904.1 → NP_001118376.1  replicon protein A2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118376.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZQ19
    UniProtKB/TrEMBL
    A0A178VTA7, A0A5S9X106
    Conserved Domains (2) summary
    cd04478
    Location:72 → 165
    RPA2_DBD_D; A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    pfam08784
    Location:163 → 272
    RPA_C; Replication protein A C terminal

  2. NM_128010.3 → NP_565571.1  replicon protein A2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565571.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZQ19
    UniProtKB/TrEMBL
    A0A178VTA7, A0A5S9X106
    Conserved Domains (2) summary
    cd04478
    Location:72 → 165
    RPA2_DBD_D; A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    pfam08784
    Location:163 → 272
    RPA_C; Replication protein A C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZQ19.2

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