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SCA3 DNA/RNA polymerases superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816946, updated on 18-Sep-2024

Summary

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Official Symbol
SCA3
Official Full Name
DNA/RNA polymerases superfamily protein
Primary source
TAIR:AT2G24120
Locus tag
AT2G24120
See related
Araport:AT2G24120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F27D4.3; F27D4_3; PDE319; PIGMENT DEFECTIVE 319; SCABRA 3
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Genomic context

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See SCA3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
19
Sequence:
Chromosome: 2; NC_003071.7 (10248851..10254641, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Leucine-rich receptor-like protein kinase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Analysis of SCA3/MJD3 gene mutation and genetic polymorphism in a guangxi family with spinocerebellar ataxia 3]. Chang RN, et al. Yi Chuan, 2013 Nov. PMID 24579313
  2. The SCABRA3 nuclear gene encodes the plastid RpoTp RNA polymerase, which is required for chloroplast biogenesis and mesophyll cell proliferation in Arabidopsis. Hricová A, et al. Plant Physiol, 2006 Jul. PMID 16698900, Free PMC Article
  3. Impaired function of the phage-type RNA polymerase RpoTp in transcription of chloroplast genes is compensated by a second phage-type RNA polymerase. Swiatecka-Hagenbruch M, et al. Nucleic Acids Res, 2008 Feb. PMID 18084023, Free PMC Article
  4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
  5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exon 10 of the SCA3 gene contains 64-71 CAG repeats in all of the affected individuals.
    Title: [Analysis of SCA3/MJD3 gene mutation and genetic polymorphism in a guangxi family with spinocerebellar ataxia 3].
  2. evidence for nuclear-encoded RNA polymerases being represented by two phage-type RNA polymerases (RpoTp and RpoTmp) that have overlapping as well as gene-specific functions in the transcription of plastidial genes.
    Title: Impaired function of the phage-type RNA polymerase RpoTp in transcription of chloroplast genes is compensated by a second phage-type RNA polymerase.
  3. findings support a role for plastids in leaf morphogenesis and indicates that RpoTp is required for mesophyll cell proliferation
    Title: The SCABRA3 nuclear gene encodes the plastid RpoTp RNA polymerase, which is required for chloroplast biogenesis and mesophyll cell proliferation in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_127973.5
NM_201796.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
DNA/RNA polymerases superfamily protein
NP_179989.1
  • SCABRA 3 (SCA3); FUNCTIONS IN: DNA-directed RNA polymerase activity, protein binding, DNA binding; INVOLVED IN: transcription; LOCATED IN: mitochondrion; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, bacteriophage type (InterPro:IPR002092); BEST Arabidopsis thaliana protein match is: male gametophyte defective 3 (TAIR:AT1G68990.1); Has 1315 Blast hits to 1296 proteins in 334 species: Archae - 0; Bacteria - 38; Metazoa - 134; Fungi - 224; Plants - 204; Viruses - 139; Other Eukaryotes - 576 (source: NCBI BLink).
NP_973525.2
  • SCABRA 3 (SCA3); FUNCTIONS IN: DNA-directed RNA polymerase activity, protein binding, DNA binding; INVOLVED IN: transcription; LOCATED IN: mitochondrion; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, bacteriophage type (InterPro:IPR002092); BEST Arabidopsis thaliana protein match is: male gametophyte defective 3 (TAIR:AT1G68990.1); Has 1200 Blast hits to 1186 proteins in 332 species: Archae - 0; Bacteria - 40; Metazoa - 130; Fungi - 220; Plants - 200; Viruses - 136; Other Eukaryotes - 474 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    10248851..10254641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127973.5 → NP_179989.1  DNA/RNA polymerases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179989.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O24600, Q0WN04
    UniProtKB/TrEMBL
    A0A5S9X0T4, A0A654EVL5
    Conserved Domains (2) summary
    COG5108
    Location:162 → 992
    RPO41; Mitochondrial DNA-directed RNA polymerase [Transcription]
    pfam00940
    Location:602 → 992
    RNA_pol; DNA-dependent RNA polymerase

  2. NM_201796.2 → NP_973525.2  DNA/RNA polymerases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973525.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W214, F4INQ5
    Conserved Domains (2) summary
    pfam00940
    Location:602 → 879
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:165 → 478
    RPOL_N; DNA-directed RNA polymerase N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O24600.1

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