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REXO5 RNA exonuclease 5 [ Homo sapiens (human) ]

Gene ID: 81691, updated on 11-Jun-2021

Summary

Official Symbol
REXO5provided by HGNC
Official Full Name
RNA exonuclease 5provided by HGNC
Primary source
HGNC:HGNC:24661
See related
Ensembl:ENSG00000005189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEF-sp
Expression
Restricted expression toward testis (RPKM 183.5) See more
Orthologs
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Genomic context

See REXO5 in Genome Data Viewer
Location:
16p12.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (20806429..20849682)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20817849..20860987)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium chain family member 4 pseudogene Neighboring gene THUMP domain containing 1 Neighboring gene acyl-CoA synthetase medium chain family member 3 Neighboring gene RNA, U6 small nuclear 944, pseudogene Neighboring gene ERI1 exoribonuclease family member 2 Neighboring gene uncharacterized LOC105371121 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene LYR motif containing 1 Neighboring gene dynein axonemal heavy chain 3 Neighboring gene uncharacterized LOC107984888

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434J0315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA exonuclease 5
Names
exonuclease NEF-sp
putative RNA exonuclease NEF-sp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144924.2NP_001138396.1  RNA exonuclease 5 isoform 2

    See identical proteins and their annotated locations for NP_001138396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC004381, AL136763, BC068503
    Consensus CDS
    CCDS45437.1
    UniProtKB/Swiss-Prot
    Q96IC2
    Related
    ENSP00000261378.8, ENST00000348433.10
    Conserved Domains (3) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    COG0847
    Location:258394
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl17169
    Location:571641
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001199053.2NP_001185982.1  RNA exonuclease 5 isoform 1

    See identical proteins and their annotated locations for NP_001185982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC004381, AK314458, BC007646, DB059505
    Consensus CDS
    CCDS10591.1
    UniProtKB/Swiss-Prot
    Q96IC2
    UniProtKB/TrEMBL
    A0A024R390
    Related
    ENSP00000457616.1, ENST00000564274.5
    Conserved Domains (3) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cd12273
    Location:506576
    RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
    cl17169
    Location:602672
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_030941.3NP_112203.2  RNA exonuclease 5 isoform 1

    See identical proteins and their annotated locations for NP_112203.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC004381, BC007646
    Consensus CDS
    CCDS10591.1
    UniProtKB/Swiss-Prot
    Q96IC2
    UniProtKB/TrEMBL
    A0A024R390
    Related
    ENSP00000261377.6, ENST00000261377.11
    Conserved Domains (3) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cd12273
    Location:506576
    RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
    cl17169
    Location:602672
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    20806429..20849682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545963.2XP_011544265.1  RNA exonuclease 5 isoform X1

    See identical proteins and their annotated locations for XP_011544265.1

    UniProtKB/Swiss-Prot
    Q96IC2
    UniProtKB/TrEMBL
    A0A024R390
    Conserved Domains (3) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cd12273
    Location:506576
    RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
    cl17169
    Location:602672
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_011545964.2XP_011544266.1  RNA exonuclease 5 isoform X3

    Conserved Domains (4) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    COG0847
    Location:258394
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cd12273
    Location:471541
    RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
    cd12274
    Location:567637
    RRM2_NEFsp; RNA recognition motif 2 in vertebrate putative RNA exonuclease NEF-sp
  3. XM_011545965.2XP_011544267.1  RNA exonuclease 5 isoform X4

    Conserved Domains (3) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    COG0847
    Location:258394
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl17169
    Location:536606
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_005255604.2XP_005255661.1  RNA exonuclease 5 isoform X1

    See identical proteins and their annotated locations for XP_005255661.1

    UniProtKB/Swiss-Prot
    Q96IC2
    UniProtKB/TrEMBL
    A0A024R390
    Conserved Domains (3) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cd12273
    Location:506576
    RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
    cl17169
    Location:602672
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_017023739.2XP_016879228.1  RNA exonuclease 5 isoform X2

    UniProtKB/Swiss-Prot
    Q96IC2
    Conserved Domains (3) summary
    cd06145
    Location:229377
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    COG0847
    Location:258394
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl17169
    Location:571641
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_024450462.1XP_024306230.1  RNA exonuclease 5 isoform X5

    Conserved Domains (3) summary
    cd06145
    Location:1120
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cd12273
    Location:249319
    RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
    cl17169
    Location:345415
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_950856.3 RNA Sequence

    Related
    ENST00000566993.5
  2. XR_002957845.1 RNA Sequence

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