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Mmp9 matrix metallopeptidase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81687, updated on 8-May-2022

Summary

Official Symbol
Mmp9provided by RGD
Official Full Name
matrix metallopeptidase 9provided by RGD
Primary source
RGD:621320
See related
Ensembl:ENSRNOG00000017539 AllianceGenome:RGD:621320
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 39.9), Kidney (RPKM 35.9) and 6 other tissues See more
Orthologs
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Genomic context

See Mmp9 in Genome Data Viewer
Location:
3q42
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153684158..153692118)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161413410..161421473)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein FLJ40606 Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene zinc finger protein 335 Neighboring gene uncharacterized LOC108350521 Neighboring gene solute carrier family 12 member 5 Neighboring gene nuclear receptor coactivator 5 Neighboring gene uncharacterized LOC120101785

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metalloendopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to UV-A IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cell-matrix adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to iron(III) ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryo implantation ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cation channel activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell differentiation involved in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epithelial cell differentiation involved in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in ossification IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in parturition IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor binding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to high light intensity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in skeletal system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transformation of host cell by virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
matrix metalloproteinase-9
Names
92 kDa gelatinase
92-kDa type IV collagenase
GELB
MMP-9
gelatinase B
matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
NP_112317.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031055.2NP_112317.2  matrix metalloproteinase-9 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000120
    Related
    ENSRNOP00000023965.1, ENSRNOT00000023965.4
    Conserved Domains (5) summary
    smart00059
    Location:224272
    FN2; Fibronectin type 2 domain
    cd00094
    Location:517707
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam04886
    Location:475510
    PT; PT repeat
    pfam00413
    Location:116445
    Peptidase_M10; Matrixin
    pfam01471
    Location:4195
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    153684158..153692118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)