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Mlh1 mutL homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81685, updated on 12-Aug-2018

Summary

Official Symbol
Mlh1provided by RGD
Official Full Name
mutL homolog 1provided by RGD
Primary source
RGD:620937
See related
Ensembl:ENSRNOG00000033809
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may be involved in DNA mismatch repair [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 108.9), Thymus (RPKM 75.0) and 9 other tissues See more
Orthologs

Genomic context

See Mlh1 in Genome Data Viewer
Location:
8q32
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119486655..119523716, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (118828172..118865320, complement)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552504 Neighboring gene uncharacterized LOC102556485 Neighboring gene LRR binding FLII interacting protein 2 Neighboring gene EPM2A interacting protein 1 Neighboring gene tetratricopeptide repeat and ankyrin repeat containing 1 Neighboring gene uncharacterized LOC102552801

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
    BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
  • BRCA1-associated genome surveillance complex (BASC), conserved biosystem (from KEGG)
    BRCA1-associated genome surveillance complex (BASC), conserved biosystemStructural complex; Genetic information processing; Repair system
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Endometrial cancer, organism-specific biosystem (from KEGG)
    Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Endometrial cancer, conserved biosystem (from KEGG)
    Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
    Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Fanconi anemia pathway, conserved biosystem (from KEGG)
    Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Mismatch Repair, organism-specific biosystem (from REACTOME)
    Mismatch Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mismatch repair, organism-specific biosystem (from KEGG)
    Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
  • Mismatch repair, organism-specific biosystem (from WikiPathways)
    Mismatch repair, organism-specific biosystemDNA mismatch repair is a system for recognizing and repairing erroneous insertion, deletion and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairin...
  • Mismatch repair, conserved biosystem (from KEGG)
    Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
  • Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), organism-specific biosystem (from REACTOME)
    Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platinum drug resistance, organism-specific biosystem (from KEGG)
    Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Platinum drug resistance, conserved biosystem (from KEGG)
    Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
MutSalpha complex binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to MutSalpha complex binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
guanine/thymine mispair binding IEA
Inferred from Electronic Annotation
more info
 
guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
 
mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
female meiosis chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
female meiosis chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
homologous chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
isotype switching IEA
Inferred from Electronic Annotation
more info
 
isotype switching ISO
Inferred from Sequence Orthology
more info
 
male meiosis chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
male meiosis chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
meiotic chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
meiotic metaphase I plate congression IEA
Inferred from Electronic Annotation
more info
 
meiotic metaphase I plate congression ISO
Inferred from Sequence Orthology
more info
 
meiotic spindle midzone assembly IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
 
meiotic telomere clustering IEA
Inferred from Electronic Annotation
more info
 
meiotic telomere clustering ISO
Inferred from Sequence Orthology
more info
 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IEA
Inferred from Electronic Annotation
more info
 
mismatch repair ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic recombination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic recombination ISO
Inferred from Sequence Orthology
more info
 
nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
oogenesis IEA
Inferred from Electronic Annotation
more info
 
oogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of isotype switching to IgA isotypes IEA
Inferred from Electronic Annotation
more info
 
positive regulation of isotype switching to IgA isotypes ISO
Inferred from Sequence Orthology
more info
 
positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 
positive regulation of isotype switching to IgG isotypes ISO
Inferred from Sequence Orthology
more info
 
reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
 
resolution of meiotic recombination intermediates IEA
Inferred from Electronic Annotation
more info
 
resolution of meiotic recombination intermediates ISO
Inferred from Sequence Orthology
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
somatic hypermutation of immunoglobulin genes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatic hypermutation of immunoglobulin genes IEA
Inferred from Electronic Annotation
more info
 
somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
 
somatic recombination of immunoglobulin gene segments ISO
Inferred from Sequence Orthology
more info
 
somatic recombination of immunoglobulin genes involved in immune response ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
synapsis IEA
Inferred from Electronic Annotation
more info
 
synapsis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
MutLalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutLalpha complex IEA
Inferred from Electronic Annotation
more info
 
MutLalpha complex ISO
Inferred from Sequence Orthology
more info
 
chiasma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chiasma IEA
Inferred from Electronic Annotation
more info
 
chiasma ISO
Inferred from Sequence Orthology
more info
 
chromosome ISO
Inferred from Sequence Orthology
more info
 
condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
late recombination nodule IEA
Inferred from Electronic Annotation
more info
 
late recombination nodule ISO
Inferred from Sequence Orthology
more info
 
male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 
synaptonemal complex IEA
Inferred from Electronic Annotation
more info
 
synaptonemal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA mismatch repair protein Mlh1
Names
mismatch repair protein 1
mutL homolog 1, colon cancer, nonpolyposis type 2
mutL protein homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031053.1NP_112315.1  DNA mismatch repair protein Mlh1

    See identical proteins and their annotated locations for NP_112315.1

    Status: PROVISIONAL

    Source sequence(s)
    U80054
    UniProtKB/Swiss-Prot
    P97679
    Related
    ENSRNOP00000072285.1, ENSRNOT00000081718.1
    Conserved Domains (4) summary
    cd03483
    Location:211335
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    TIGR00585
    Location:6315
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:503757
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl00075
    Location:31132
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    119486655..119523716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595929.1XP_017451418.1  DNA mismatch repair protein Mlh1 isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    110478307..110515168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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