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CCNL2 cyclin L2 [ Homo sapiens (human) ]

Gene ID: 81669, updated on 29-Mar-2020

Summary

Official Symbol
CCNL2provided by HGNC
Official Full Name
cyclin L2provided by HGNC
Primary source
HGNC:HGNC:20570
See related
Ensembl:ENSG00000221978 MIM:613482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO
Summary
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in skin (RPKM 45.3), endometrium (RPKM 44.2) and 25 other tissues See more
Orthologs

Genomic context

See CCNL2 in Genome Data Viewer
Location:
1p36.33
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1385711..1399342, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1321091..1334718, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene aurora kinase A interacting protein 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 8 Neighboring gene MRPL20 antisense RNA 1 Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene RNA, 7SL, cytoplasmic 657, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762O195, DKFZp761A1210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-L2
Names
cyclin M
cyclin S
paneth cell-enhanced expression protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029782.1 RefSeqGene

    Range
    5004..18628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039577.4NP_001034666.1  cyclin-L2 isoform B

    See identical proteins and their annotated locations for NP_001034666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as L2betaA3 or T3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (B), also known as L2betaA, contains the cyclin box in the N-terminus and lacks the arginine/serine-rich domain (RS domain) in the C-terminus, compared to isoform A.
    Source sequence(s)
    BC016333, DA360436, HY002650
    Consensus CDS
    CCDS30558.1
    UniProtKB/Swiss-Prot
    Q96S94
    Related
    ENSP00000386158.4, ENST00000408918.8
    Conserved Domains (1) summary
    cd00043
    Location:77150
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  2. NM_001320153.3NP_001307082.1  cyclin-L2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and uses an alternate splice junction compared to variant 1. The resulting isoform (C) is shorter at the N-terminus compared to isoform A. Variants 3, 4, 6, and 7 encode the same isoform (C).
    Source sequence(s)
    AK000685, AK056120, AK074112, AL391244, CR628411, HY002650
    UniProtKB/Swiss-Prot
    Q96S94
    Conserved Domains (1) summary
    smart00385
    Location:160
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  3. NM_001320155.3NP_001307084.1  cyclin-L2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (C) is shorter at the N-terminus compared to isoform A. Variants 3, 4, 6, and 7 encode the same isoform (C).
    Source sequence(s)
    AK000685, AK074112, AY116620, CR628411, HY002650
    UniProtKB/Swiss-Prot
    Q96S94
    Conserved Domains (1) summary
    smart00385
    Location:160
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  4. NM_001350497.1NP_001337426.1  cyclin-L2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. These differences cause translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (C) is shorter at the N-terminus compared to isoform A. Variants 3, 4, 6, and 7 encode the same isoform (C).
    Source sequence(s)
    AK000685, AK056120, AK057133, AK074112
    Conserved Domains (1) summary
    smart00385
    Location:160
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  5. NM_001350498.2NP_001337427.1  cyclin-L2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate exon compared to variant 1. The resulting isoform (C) is shorter at the N-terminus compared to isoform A. Variants 3, 4, 6, and 7 encode the same isoform (C).
    Source sequence(s)
    AK000685, AK056120, AK057133, AK074112, HY002650
    Conserved Domains (1) summary
    smart00385
    Location:160
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  6. NM_001350499.2NP_001337428.1  cyclin-L2 isoform D

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains two consecutive alternate exons, resulting in use of an alternate start codon, compared to variant 1. The resulting isoform (D) has a shorter but distinct N-terminus compared to isoform A. Variants 8 and 9 both encode the same isoform (D).
    Source sequence(s)
    AK000685, AK056120, AK074112, CN402151, DA944374, HY002650
    Conserved Domains (1) summary
    smart00385
    Location:90151
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  7. NM_001350500.2NP_001337429.1  cyclin-L2 isoform D

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains two consecutive alternate exons, resulting in use of an alternate start codon, compared to variant 1. The resulting isoform (D) has a shorter but distinct N-terminus compared to isoform A. Variants 8 and 9 both encode the same isoform (D).
    Source sequence(s)
    AK000685, AK056120, AK074112, CN402151, DA944374, HY002650
    Conserved Domains (1) summary
    smart00385
    Location:90151
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  8. NM_030937.6NP_112199.2  cyclin-L2 isoform A

    See identical proteins and their annotated locations for NP_112199.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as L2alpha or T2) encodes the longest isoform (A, also known as L2alpha) containing a cyclin box in the N-terminus and RS domain in the C-terminus.
    Source sequence(s)
    AK000685, AL834432, AY037150, HY002650
    Consensus CDS
    CCDS30557.1
    UniProtKB/Swiss-Prot
    Q96S94
    Related
    ENSP00000383611.3, ENST00000400809.8
    Conserved Domains (2) summary
    smart00385
    Location:200282
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
    cd00043
    Location:77150
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RNA

  1. NR_135154.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains two alternate exons and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK000685, AK074112, HY172534
    Related
    ENST00000496007.5
  2. NR_146722.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains multiple internal alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD)
    Source sequence(s)
    AK000685, AK056120, AK074112, DA944374, DA954161, DN994809, HY002650
  3. NR_146723.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains multiple internal alternate exons and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK000685, AK056120, AK074112, DA944374, HY002650

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1385711..1399342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002420.1XP_016857909.1  cyclin-L2 isoform X2

    Conserved Domains (1) summary
    smart00385
    Location:99160
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  2. XM_011542216.3XP_011540518.1  cyclin-L2 isoform X1

    Conserved Domains (2) summary
    smart00385
    Location:233315
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
    COG5333
    Location:69306
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
  3. XM_024450050.1XP_024305818.1  cyclin-L2 isoform X3

    Conserved Domains (1) summary
    smart00385
    Location:160
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
  4. XM_024450049.1XP_024305817.1  cyclin-L2 isoform X3

    Conserved Domains (1) summary
    smart00385
    Location:160
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma

RNA

  1. XR_001737453.1 RNA Sequence

  2. XR_426630.3 RNA Sequence

  3. XR_002957678.1 RNA Sequence

  4. XR_001737455.1 RNA Sequence

  5. XR_002957684.1 RNA Sequence

  6. XR_001737452.1 RNA Sequence

  7. XR_001737454.1 RNA Sequence

  8. XR_002957676.1 RNA Sequence

  9. XR_946769.2 RNA Sequence

  10. XR_002957683.1 RNA Sequence

  11. XR_001737450.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001144867.1: Suppressed sequence

    Description
    NM_001144867.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001144868.1: Suppressed sequence

    Description
    NM_001144868.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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