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Gnai2 G protein subunit alpha i2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81664, updated on 6-May-2021

Summary

Official Symbol
Gnai2provided by RGD
Official Full Name
G protein subunit alpha i2provided by RGD
Primary source
RGD:620243
See related
Ensembl:ENSRNOG00000016592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Galphai2
Summary
plays a role in prostaglandin (PG)F2alpha activation of ERK1 and ERK2 signaling [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 1061.4), Spleen (RPKM 871.4) and 9 other tissues See more
Orthologs
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Genomic context

See Gnai2 in Genome Data Viewer
Location:
8q32
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108288401..108309009, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116370730..116391337, complement)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene interferon-related developmental regulator 2 Neighboring gene leucine-rich single-pass membrane protein 2 Neighboring gene semaphorin 3B Neighboring gene uncharacterized LOC120094260 Neighboring gene solute carrier family 38, member 3 Neighboring gene uncharacterized LOC120094261

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled adenosine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled adenosine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in G protein-coupled glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gamma-aminobutyric acid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NAD(P)H oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-2
Names
G alpha inhibitory type 2 (a)
G alpha inhibitory type 2 (b)
GTP-binding protein (G-alpha-i2)
adenylate cyclase-inhibiting G alpha protein
guanine nucleotide binding protein (G protein), alpha inhibiting 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
guanine nucleotide binding protein, alpha inhibiting 2
guanine nucleotide-binding protein G(i), alpha-2 subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031035.3NP_112297.1  guanine nucleotide-binding protein G(i) subunit alpha-2

    See identical proteins and their annotated locations for NP_112297.1

    Status: VALIDATED

    Source sequence(s)
    BC078806, CO394955, CR465951
    UniProtKB/Swiss-Prot
    P04897
    UniProtKB/TrEMBL
    Q45QN0
    Related
    ENSRNOP00000022550.4, ENSRNOT00000022550.6
    Conserved Domains (1) summary
    cd00066
    Location:34349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    108288401..108309009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243858.1XP_006243920.1  guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006243920.1

    UniProtKB/Swiss-Prot
    P04897
    UniProtKB/TrEMBL
    Q45QN0
    Conserved Domains (1) summary
    cd00066
    Location:34349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
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