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Gna12 G protein subunit alpha 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81663, updated on 18-Apr-2019

Summary

Official Symbol
Gna12provided by RGD
Official Full Name
G protein subunit alpha 12provided by RGD
Primary source
RGD:71018
See related
Ensembl:ENSRNOG00000001235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may play a role in D5 dopamine receptor signal transduction and renal sodium transport [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 377.5), Heart (RPKM 344.9) and 9 other tissues See more
Orthologs

Genomic context

See Gna12 in Genome Data Viewer
Location:
12q11
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (15890202..15971212)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (17889996..17970852)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547234 Neighboring gene caspase recruitment domain family, member 11 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene BRCA1-associated ATM activator 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
D5 dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
D5 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
dopamine receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
PubMed 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-12
Names
g alpha-12
guanine nucleotide binding protein (G protein) alpha 12
guanine nucleotide binding protein, alpha 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031034.2NP_112296.1  guanine nucleotide-binding protein subunit alpha-12

    See identical proteins and their annotated locations for NP_112296.1

    Status: VALIDATED

    Source sequence(s)
    AABR07035471, AC119536
    UniProtKB/Swiss-Prot
    Q63210
    UniProtKB/TrEMBL
    Q45QM2
    Related
    ENSRNOP00000001654.5, ENSRNOT00000001654.7
    Conserved Domains (2) summary
    cd00066
    Location:56373
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:40377
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    15890202..15971212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    15567135..15646904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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