Format

Send to:

Choose Destination

AKAP1 A-kinase anchoring protein 1 [ Homo sapiens (human) ]

Gene ID: 8165, updated on 3-Jun-2018
Official Symbol
AKAP1provided by HGNC
Official Full Name
A-kinase anchoring protein 1provided by HGNC
Primary source
HGNC:HGNC:367
See related
Ensembl:ENSG00000121057 MIM:602449; Vega:OTTHUMG00000140369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKAP; PRKA1; AKAP84; TDRD17; AKAP121; AKAP149; D-AKAP1; PPP1R43; SAKAP84
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 41.4), heart (RPKM 27.0) and 24 other tissues See more
Orthologs
See AKAP1 in Genome Data Viewer
Location:
17q22
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (57085192..57121349)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55162553..55198710)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene serine carboxypeptidase 1 Neighboring gene ring finger protein 126 pseudogene 1 Neighboring gene uncharacterized LOC101927510 Neighboring gene musashi RNA binding protein 2 Neighboring gene uncharacterized LOC101927557

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
reverse transcriptase gag-pol AKAP149 is an HIV-1 RT binding protein. Amino acids 375-645 of APAK149 and amino acids 464-541 of HIV-1 RT p66 are involved in the binding between APAK149 and RT p66. A single-point mutant RT G462R fails to carry out reverse transcription PubMed

Go to the HIV-1, Human Interaction Database

  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC1807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
regulation of protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
Preferred Names
A-kinase anchor protein 1, mitochondrial
Names
A kinase (PRKA) anchor protein 1
A-kinase anchor protein 149 kDa
AKAP 149
D-AKAP-1
dual-specificity A-kinase anchoring protein 1
protein kinase A anchoring protein 1
protein kinase A1
protein phosphatase 1, regulatory subunit 43
spermatid A-kinase anchor protein 84
testicular secretory protein Li 5
tudor domain containing 17

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029985.1 RefSeqGene

    Range
    5001..41158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242902.1NP_001229831.1  A-kinase anchor protein 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001229831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5'UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK297810, BC000729, BM711930, CB048239, CD172211
    Consensus CDS
    CCDS11594.1
    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05, B4DN86
    Related
    ENSP00000459968.1, OTTHUMP00000258572, ENST00000571629.5, OTTHUMT00000440641
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)
  2. NM_001242903.1NP_001229832.1  A-kinase anchor protein 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001229832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5'UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK308397, BC000729, BM711930, CB048239, CD172211, DA092401
    Consensus CDS
    CCDS11594.1
    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05
    Related
    ENSP00000478212.1, ENST00000621116.4
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)
  3. NM_003488.3NP_003479.1  A-kinase anchor protein 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_003479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest first intron.
    Source sequence(s)
    AC007114, BC000729, DA455114, X97335
    Consensus CDS
    CCDS11594.1
    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05
    Related
    ENSP00000337736.3, OTTHUMP00000179121, ENST00000337714.7, OTTHUMT00000277069
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    57085192..57121349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257707.3XP_005257764.1  A-kinase anchor protein 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005257764.1

    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)
  2. XM_017025189.2XP_016880678.1  A-kinase anchor protein 1, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)
  3. XM_005257709.3XP_005257766.1  A-kinase anchor protein 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005257766.1

    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)
  4. XM_017025191.2XP_016880680.1  A-kinase anchor protein 1, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)
  5. XM_017025190.2XP_016880679.1  A-kinase anchor protein 1, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q92667
    UniProtKB/TrEMBL
    A0A140VK05
    Related
    ENSP00000459895.1, OTTHUMP00000258578, ENST00000572557.5
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)
  6. XM_024450960.1XP_024306728.1  A-kinase anchor protein 1, mitochondrial isoform X1

    Related
    ENSP00000443139.1, ENST00000539273.5
    Conserved Domains (3) summary
    cd00105
    Location:611671
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:704826
    TUDOR; Tudor domain
    cl25602
    Location:181380
    DUF3552; Domain of unknown function (DUF3552)

RNA

  1. XR_001752655.2 RNA Sequence

    Related
    ENST00000481416.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_139275.1: Suppressed sequence

    Description
    NM_139275.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center