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Creb1 cAMP responsive element binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81646, updated on 10-Oct-2024

Summary

Official Symbol
Creb1provided by RGD
Official Full Name
cAMP responsive element binding protein 1provided by RGD
Primary source
RGD:620218
See related
EnsemblRapid:ENSRNOG00000013412 AllianceGenome:RGD:620218
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Creb
Summary
Enables several functions, including Hsp70 protein binding activity; arrestin family protein binding activity; and histone acetyltransferase binding activity. Involved in several processes, including cellular response to growth factor stimulus; learning or memory; and regulation of gene expression. Located in several cellular components, including axon; chromatin; and mitochondrial matrix. Part of transcription regulator complex. Used to study transient cerebral ischemia. Biomarker of Huntington's disease; brain ischemia; and sciatic neuropathy. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 198.6), Spleen (RPKM 141.8) and 9 other tissues See more
Orthologs
NEW
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Genomic context

See Creb1 in Genome Data Viewer
Location:
9q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73397333..73466339)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (65903511..65972562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71229753..71298994)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 7-like Neighboring gene uncharacterized LOC134480377 Neighboring gene methyltransferase 21A, HSPA lysine Neighboring gene uncharacterized LOC134480378 Neighboring gene uncharacterized LOC120094695 Neighboring gene uncharacterized LOC134480380

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables arrestin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin-like growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis to arachidonate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lactation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung epithelium development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung saccule development ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta3 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of testosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to L-glutamate IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to dehydroepiandrosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to erythropoietin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucagon ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucagon ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to hypobaric hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to morphine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to purine-containing compound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within secretory granule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ATF4-CREB1 transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 1
Names
CREB-1
Y protein
cAMP response element binding protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031017.2NP_112279.1  cyclic AMP-responsive element-binding protein 1 isoform B

    See identical proteins and their annotated locations for NP_112279.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8L2QQ18, A6IPH8
    Related
    ENSRNOP00000018326.1, ENSRNOT00000018326.7
    Conserved Domains (2) summary
    cd14690
    Location:285339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:113151
    pKID; pKID domain
  2. NM_134443.2NP_604392.2  cyclic AMP-responsive element-binding protein 1 isoform A

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P15337
    UniProtKB/TrEMBL
    A0A8L2QQ18, A6IPH9
    Related
    ENSRNOP00000087190.2, ENSRNOT00000115911.2
    Conserved Domains (2) summary
    cd14690
    Location:271325
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:99137
    pKID; pKID domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    73397333..73466339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084245.2XP_038940173.1  cyclic AMP-responsive element-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QQ18, A6IPH8
    Conserved Domains (2) summary
    cd14690
    Location:285339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:113151
    pKID; pKID domain
  2. XM_039084247.2XP_038940175.1  cyclic AMP-responsive element-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02173
    Location:113151
    pKID; pKID domain
  3. XM_063267770.1XP_063123840.1  cyclic AMP-responsive element-binding protein 1 isoform X3

  4. XM_063267771.1XP_063123841.1  cyclic AMP-responsive element-binding protein 1 isoform X3

  5. XM_006245070.4XP_006245132.1  cyclic AMP-responsive element-binding protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006245132.1

    UniProtKB/TrEMBL
    A0A8I5YBW8
    Conserved Domains (1) summary
    cd14690
    Location:55109
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

RNA

  1. XR_005488972.2 RNA Sequence

  2. XR_010054634.1 RNA Sequence