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Alox15 arachidonate 15-lipoxygenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81639, updated on 17-Nov-2020

Summary

Official Symbol
Alox15provided by RGD
Official Full Name
arachidonate 15-lipoxygenaseprovided by RGD
Primary source
RGD:70493
See related
Ensembl:ENSRNOG00000019183
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
12-LOX; 15-LOX; Alox12; Alox12l
Summary
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 2807.1), Lung (RPKM 941.1) and 1 other tissue See more

Genomic context

See Alox15 in Genome Data Viewer
Location:
10q24
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56953692..56962145, complement)
106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (54211640..54220083, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56704488..56713186, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene arachidonate 12-lipoxygenase, 12S type Neighboring gene arachidonate 12-lipoxygenase, epidermal Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene arrestin, beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
arachidonate 12(S)-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonate 12(S)-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 12(S)-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
arachidonate 15-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 15-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
hepoxilin A3 synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
hepoxilin-epoxide hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
linoleate 13S-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
linoleate 13S-lipoxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
bone mineralization ISO
Inferred from Sequence Orthology
more info
 
bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-13 ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-13 ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hepoxilin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
icosanoid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
linoleic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoxin A4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipoxin A4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell volume TAS
Traceable Author Statement
more info
PubMed 
ossification ISO
Inferred from Sequence Orthology
more info
 
ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylethanolamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of engulfment of apoptotic cell ISO
Inferred from Sequence Orthology
more info
 
regulation of engulfment of apoptotic cell ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of membrane potential TAS
Traceable Author Statement
more info
PubMed 
regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid droplet ISO
Inferred from Sequence Orthology
more info
 
lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX15; arachidonate 15-lipoxygenase
Names
12/15-LOX
12/15-lipoxygenase
arachidonate 12-lipoxygenase, leukocyte-type
arachidonate omega-6 lipoxygenase
hepoxilin A3 synthase Alox15
linoleate 13S-lipoxygenase
NP_112272.2
XP_006246885.1
XP_006246886.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031010.2NP_112272.2  polyunsaturated fatty acid lipoxygenase ALOX15

    See identical proteins and their annotated locations for NP_112272.2

    Status: PROVISIONAL

    Source sequence(s)
    S69383
    UniProtKB/Swiss-Prot
    Q02759
    Related
    ENSRNOP00000026038.4, ENSRNOT00000026038.6
    Conserved Domains (2) summary
    cd01753
    Location:2112
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:214654
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    56953692..56962145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246824.3XP_006246886.1  arachidonate 15-lipoxygenase isoform X2

    Conserved Domains (2) summary
    pfam00305
    Location:244684
    Lipoxygenase; Lipoxygenase
    cl00011
    Location:75142
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
  2. XM_006246823.3XP_006246885.1  arachidonate 15-lipoxygenase isoform X1

    Conserved Domains (2) summary
    pfam00305
    Location:279719
    Lipoxygenase; Lipoxygenase
    cl00011
    Location:110177
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    54211640..54220083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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