Format

Send to:

Choose Destination

Acta2 actin, alpha 2, smooth muscle, aorta [ Rattus norvegicus (Norway rat) ]

Gene ID: 81633, updated on 3-Jun-2018
Official Symbol
Acta2provided by RGD
Official Full Name
actin, alpha 2, smooth muscle, aortaprovided by RGD
Primary source
RGD:621676
See related
Ensembl:ENSRNOG00000058039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
contractile protein; required for extracellular matrix remodeling [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 1292.3), Spleen (RPKM 312.3) and 6 other tissues See more
Orthologs
See Acta2 in Genome Data Viewer
Location:
1q52
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252537614..252550394, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (259760521..259773301, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 22 Neighboring gene STAM binding protein-like 1 Neighboring gene similar to death effector domain-containing Neighboring gene Fas cell surface death receptor

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
glomerular mesangial cell development IEA
Inferred from Electronic Annotation
more info
 
glomerular mesangial cell development ISO
Inferred from Sequence Orthology
more info
 
mesenchyme migration ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hepatic stellate cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hepatic stellate cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hepatic stellate cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to virus IEA
Inferred from Electronic Annotation
more info
 
response to virus ISO
Inferred from Sequence Orthology
more info
 
vascular smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
vascular smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
smooth muscle contractile fiber IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contractile fiber ISO
Inferred from Sequence Orthology
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
actin, aortic smooth muscle
Names
alpha-actin-2
smooth muscle alpha-actin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031004.2NP_112266.1  actin, aortic smooth muscle

    See identical proteins and their annotated locations for NP_112266.1

    Status: VALIDATED

    Source sequence(s)
    BI282383, BI287899, CB608976, DN934985
    UniProtKB/Swiss-Prot
    P62738
    UniProtKB/TrEMBL
    B0BMT0
    Related
    ENSRNOP00000073101.1, ENSRNOT00000083468.1
    Conserved Domains (1) summary
    PTZ00281
    Location:3377
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    252537614..252550394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    228860239..228873019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center