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Acta2 actin alpha 2, smooth muscle [ Rattus norvegicus (Norway rat) ]

Gene ID: 81633, updated on 24-May-2022

Summary

Official Symbol
Acta2provided by RGD
Official Full Name
actin alpha 2, smooth muscleprovided by RGD
Primary source
RGD:621676
See related
Ensembl:ENSRNOG00000058039 AllianceGenome:RGD:621676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of cellular component movement; and positive regulation of hepatic stellate cell activation. Located in cytoplasm and stress fiber. Human ortholog(s) of this gene implicated in Moyamoya disease and thoracic aortic aneurysm. Orthologous to human ACTA2 (actin alpha 2, smooth muscle). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 1292.3), Spleen (RPKM 312.3) and 6 other tissues See more
Orthologs
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Genomic context

See Acta2 in Genome Data Viewer
Location:
1q52
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (231746527..231759307, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252537614..252550394, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100022 Neighboring gene STAM binding protein-like 1 Neighboring gene death effector domain-containing, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene Fas cell surface death receptor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in glomerular mesangial cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerular mesangial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchyme migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of hepatic stellate cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hepatic stellate cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hepatic stellate cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular associated smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vascular associated smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in smooth muscle contractile fiber IEA
Inferred from Electronic Annotation
more info
 
located_in smooth muscle contractile fiber ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin, aortic smooth muscle
Names
actin, alpha 2, smooth muscle, aorta
alpha-actin-2
smooth muscle alpha-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031004.2NP_112266.1  actin, aortic smooth muscle

    See identical proteins and their annotated locations for NP_112266.1

    Status: VALIDATED

    Source sequence(s)
    BI282383, BI287899, CB608976, DN934985
    UniProtKB/Swiss-Prot
    P62738
    UniProtKB/TrEMBL
    B0BMT0
    Related
    ENSRNOP00000073101.2, ENSRNOT00000083468.2
    Conserved Domains (1) summary
    PTZ00281
    Location:3377
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    231746527..231759307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)