U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TSSK3 testis specific serine kinase 3 [ Homo sapiens (human) ]

Gene ID: 81629, updated on 8-Dec-2022

Summary

Official Symbol
TSSK3provided by HGNC
Official Full Name
testis specific serine kinase 3provided by HGNC
Primary source
HGNC:HGNC:15473
See related
Ensembl:ENSG00000162526 MIM:607660; AllianceGenome:HGNC:15473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSK3; SPOGA3; STK22C; STK22D
Summary
This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 12.3), bone marrow (RPKM 7.8) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TSSK3 in Genome Data Viewer
Location:
1p35.1
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32362539..32364312)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32220454..32222227)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32828140..32829913)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378629 Neighboring gene Sharpr-MPRA regulatory region 14076 Neighboring gene uncharacterized LOC124903933 Neighboring gene family with sequence similarity 229 member A Neighboring gene BSD domain containing 1 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific serine/threonine-protein kinase 3
Names
TSK-3
TSSK-3
serine/threonine-protein kinase 22C
spermiogenesis associated 3
testis-specific kinase 3
testis-specific serine/threonine kinase 22C
NP_443073.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052841.4NP_443073.1  testis-specific serine/threonine-protein kinase 3

    See identical proteins and their annotated locations for NP_443073.1

    Status: REVIEWED

    Source sequence(s)
    BC035354
    Consensus CDS
    CCDS362.1
    UniProtKB/Swiss-Prot
    Q5TEE5, Q96PN8
    Related
    ENSP00000362634.3, ENST00000373534.4
    Conserved Domains (2) summary
    smart00220
    Location:10265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14163
    Location:9265
    STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    32362539..32364312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    32220454..32222227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)