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TSSK3 testis specific serine kinase 3 [ Homo sapiens (human) ]

Gene ID: 81629, updated on 7-Jun-2020

Summary

Official Symbol
TSSK3provided by HGNC
Official Full Name
testis specific serine kinase 3provided by HGNC
Primary source
HGNC:HGNC:15473
See related
Ensembl:ENSG00000162526 MIM:607660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSK3; SPOGA3; STK22C; STK22D
Summary
This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 12.3), bone marrow (RPKM 7.8) and 23 other tissues See more
Orthologs

Genomic context

See TSSK3 in Genome Data Viewer
Location:
1p35.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (32352720..32365265)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32818365..32830098)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MARCKS like 1 Neighboring gene uncharacterized LOC105378629 Neighboring gene family with sequence similarity 229 member A Neighboring gene BSD domain containing 1 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 20 Neighboring gene leucine rich repeat containing 37 member A12, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific serine/threonine-protein kinase 3
Names
TSK-3
TSSK-3
serine/threonine-protein kinase 22C
spermiogenesis associated 3
testis-specific kinase 3
testis-specific serine/threonine kinase 22C
NP_443073.1
XP_024305809.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052841.4NP_443073.1  testis-specific serine/threonine-protein kinase 3

    See identical proteins and their annotated locations for NP_443073.1

    Status: REVIEWED

    Source sequence(s)
    BC035354
    Consensus CDS
    CCDS362.1
    UniProtKB/Swiss-Prot
    Q96PN8
    Related
    ENSP00000362634.3, ENST00000373534.4
    Conserved Domains (2) summary
    smart00220
    Location:10265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14163
    Location:9265
    STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    32352720..32365265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450041.1XP_024305809.1  testis-specific serine/threonine-protein kinase 3 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1190
    PKc_like; Protein Kinases, catalytic domain
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