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TSC22D4 TSC22 domain family member 4 [ Homo sapiens (human) ]

Gene ID: 81628, updated on 5-Jul-2020

Summary

Official Symbol
TSC22D4provided by HGNC
Official Full Name
TSC22 domain family member 4provided by HGNC
Primary source
HGNC:HGNC:21696
See related
Ensembl:ENSG00000166925 MIM:611914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THG1; THG-1; TILZ2
Summary
TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 27.0), spleen (RPKM 25.5) and 25 other tissues See more
Orthologs

Genomic context

See TSC22D4 in Genome Data Viewer
Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100466519..100479214, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100064142..100076902, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr7.3510 Neighboring gene chromosome 7 open reading frame 61 Neighboring gene Sharpr-MPRA regulatory region 1011 Neighboring gene neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 Neighboring gene uncharacterized LOC107986829

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to osmotic stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TSC22 domain family protein 4
Names
TSC22-related-inducible leucine zipper protein 2
tsc-22-like protein THG-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303043.2NP_001289972.1  TSC22 domain family protein 4 isoform a

    See identical proteins and their annotated locations for NP_001289972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR. Variants 1 and 2 encode the protein.
    Source sequence(s)
    AA991748, AK296580, AK314824, BC001486, BC010406
    Consensus CDS
    CCDS5695.1
    UniProtKB/Swiss-Prot
    Q9Y3Q8
    UniProtKB/TrEMBL
    B4DKI8
    Conserved Domains (2) summary
    pfam10018
    Location:137224
    Med4; Vitamin-D-receptor interacting Mediator subunit 4
    pfam01166
    Location:326380
    TSC22; TSC-22/dip/bun family
  2. NM_030935.5NP_112197.1  TSC22 domain family protein 4 isoform a

    See identical proteins and their annotated locations for NP_112197.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the protein.
    Source sequence(s)
    AA991748, AC092849, AK296580, BC001486, BC010406
    Consensus CDS
    CCDS5695.1
    UniProtKB/Swiss-Prot
    Q9Y3Q8
    UniProtKB/TrEMBL
    B4DKI8
    Related
    ENSP00000300181.2, ENST00000300181.7
    Conserved Domains (2) summary
    pfam10018
    Location:137224
    Med4; Vitamin-D-receptor interacting Mediator subunit 4
    pfam01166
    Location:326380
    TSC22; TSC-22/dip/bun family

RNA

  1. NR_130118.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA991748, AC092849, AK296580, AK297702, BC001486, BC010406
  2. NR_130119.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA991748, AK296580, BC001486, BC010406, BX341171
    Related
    ENST00000393991.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100466519..100479214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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