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TRMT1L tRNA methyltransferase 1 like [ Homo sapiens (human) ]

Gene ID: 81627, updated on 21-Dec-2019

Summary

Official Symbol
TRMT1Lprovided by HGNC
Official Full Name
tRNA methyltransferase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:16782
See related
Ensembl:ENSG00000121486 MIM:611673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM1L; MST070; C1orf25; MSTP070; bG120K12.3
Summary
This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]
Expression
Broad expression in testis (RPKM 9.7), kidney (RPKM 3.9) and 24 other tissues See more
Orthologs

Genomic context

See TRMT1L in Genome Data Viewer
Location:
1q25.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (185118085..185157098, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185087217..185126230, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 72 Neighboring gene ring finger protein 2 Neighboring gene ferritin heavy chain 1 pseudogene 25 Neighboring gene ribosomal protein L22 pseudogene 24 Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ribosomal protein L5 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with tRNA methyltransferase 1 homolog (S. cerevisiae)-like (TRMT1L) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Rev rev HIV-1 Rev interacting protein, TRMT1-like protein, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25112, MGC57134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
tRNA (guanine-N2-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
behavior IEA
Inferred from Electronic Annotation
more info
 
tRNA N2-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TRMT1-like protein
Names
TRM1 tRNA methyltransferase 1-like
TRM1-like protein
tRNA methyltransferase 1 homolog-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202423.1NP_001189352.1  TRMT1-like protein isoform 2

    See identical proteins and their annotated locations for NP_001189352.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF163261, AK074993, AK226103, AK302166, BU198525, DC398320
    UniProtKB/Swiss-Prot
    Q7Z2T5
    UniProtKB/TrEMBL
    B4DXX1
    Conserved Domains (1) summary
    cl17173
    Location:95536
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_030934.5NP_112196.3  TRMT1-like protein isoform 1

    See identical proteins and their annotated locations for NP_112196.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF288399, AK226103, BC045535, DB093548
    Consensus CDS
    CCDS1366.1
    UniProtKB/Swiss-Prot
    Q7Z2T5
    Related
    ENSP00000356476.5, ENST00000367506.10
    Conserved Domains (1) summary
    cl17173
    Location:251692
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    185118085..185157098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002419.2XP_016857908.1  TRMT1-like protein isoform X1

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