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SHCBP1L SHC binding and spindle associated 1 like [ Homo sapiens (human) ]

Gene ID: 81626, updated on 5-Jan-2022

Summary

Official Symbol
SHCBP1Lprovided by HGNC
Official Full Name
SHC binding and spindle associated 1 likeprovided by HGNC
Primary source
HGNC:HGNC:16788
See related
Ensembl:ENSG00000157060 MIM:619514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GE36; C1orf14
Summary
This gene encodes a Src homology 2 domain-binding protein 1-like protein. The encoded protein interacts with heat shock 70 kDa protein 2 and may be involved in maintaining spindle integrity during meiosis. This gene is located in region of chromoso0me 1 encompassing a prostate cancer susceptibility locus. [provided by RefSeq, Sep 2016]
Expression
Restricted expression toward testis (RPKM 73.5) See more
Orthologs
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Genomic context

See SHCBP1L in Genome Data Viewer
Location:
1q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (182899865..182953166, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182869000..182922301, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene DHX9 antisense RNA 1 Neighboring gene DExH-box helicase 9 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 4 Neighboring gene RNA, 5S ribosomal pseudogene 71 Neighboring gene natural cytotoxicity triggering receptor 1 pseudogene Neighboring gene keratin 18 pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26911, MGC48296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in male meiosis cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of chromosome organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in meiotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in meiotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
testicular spindle-associated protein SHCBP1L
Names
SHC SH2 domain-binding protein 1-like protein
SHC SH2-domain binding protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051596.1 RefSeqGene

    Range
    5360..58661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345928.2NP_001332857.1  testicular spindle-associated protein SHCBP1L isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1.
    Source sequence(s)
    AF288397, AL450304, AL662837, BC026084
    UniProtKB/Swiss-Prot
    Q9BZQ2
    Related
    ENST00000483655.5
  2. NM_030933.4NP_112195.2  testicular spindle-associated protein SHCBP1L isoform 1

    See identical proteins and their annotated locations for NP_112195.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF288398, AL450304, AL662837, BC050305
    Consensus CDS
    CCDS30955.1
    UniProtKB/Swiss-Prot
    Q9BZQ2
    Related
    ENSP00000356518.3, ENST00000367547.8
    Conserved Domains (1) summary
    pfam13229
    Location:486653
    Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    182899865..182953166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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