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Mechanosensitive ion channel family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816204, updated on 18-Sep-2024

Summary

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Official Full Name
Mechanosensitive ion channel family protein
Primary source
TAIR:AT2G17010
Locus tag
AT2G17010
See related
Araport:AT2G17010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F6P23.17; F6P23_17
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Genomic context

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Location:
chromosome: 2
Exon count:
5
Sequence:
Chromosome: 2; NC_003071.7 (7392762..7395985, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene Mechanosensitive ion channel family protein Neighboring gene F-box/RNI-like superfamily protein Neighboring gene F-box SKIP23-like protein (DUF295)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Tension-sensitive Ion Transport Activity of MSL8 is Critical for its Function in Pollen Hydration and Germination. Hamilton ES, et al. Plant Cell Physiol, 2017 Jul 1. PMID 28339550
  2. Mechanosensitive channel MSL8 regulates osmotic forces during pollen hydration and germination. Hamilton ES, et al. Science, 2015 Oct 23. PMID 26494758, Free PMC Article
  3. SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration. Zhou X, et al. Nat Commun, 2022 Jan 10. PMID 35013278, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration.
    Title: SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration.
  2. An intact MSL8 channel is required for normal pollen function during hydration and germination. These data establish MSL8 as the first plant MS channel to fulfill previously established criteria for assignment as a mechanotransducer.
    Title: The Tension-sensitive Ion Transport Activity of MSL8 is Critical for its Function in Pollen Hydration and Germination.
  3. MSL8 thus senses and responds to changes in membrane tension associated with pollen hydration and germination.
    Title: Mechanosensitive channel MSL8 regulates osmotic forces during pollen hydration and germination.
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General gene information

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NM_001335527.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within pollen germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen hydration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in pollen tube IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mechanosensitive ion channel family protein
NP_001318236.1
  • Mechanosensitive ion channel family protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: transmembrane transport; LOCATED IN: membrane; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: Mechanosensitive ion channel family protein (TAIR:AT2G17000.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    7392762..7395985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001335528.1 → NP_001323613.1  Mechanosensitive ion channel family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AXM8

  2. NM_001335527.1 → NP_001318236.1  Mechanosensitive ion channel family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IME2
    UniProtKB/TrEMBL
    A0A178VYZ4, A0A5S9WYQ2, A0A654ETH4
    Conserved Domains (1) summary
    cl39057
    Location:706 → 876
    MS_channel; Mechanosensitive ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4IME2.2

Gene LinkOut

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