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TSPAN14 tetraspanin 14 [ Homo sapiens (human) ]

Gene ID: 81619, updated on 13-Mar-2020

Summary

Official Symbol
TSPAN14provided by HGNC
Official Full Name
tetraspanin 14provided by HGNC
Primary source
HGNC:HGNC:23303
See related
Ensembl:ENSG00000108219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TM4SF14; DC-TM4F2; tspan-14
Expression
Ubiquitous expression in fat (RPKM 22.8), placenta (RPKM 20.4) and 25 other tissues See more
Orthologs

Genomic context

See TSPAN14 in Genome Data Viewer
Location:
10q23.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (80454265..80533124)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82214038..82282394)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene DPY30 domain containing 1 Neighboring gene DPY30 domain containing 2 Neighboring gene peroxiredoxin like 2A Neighboring gene uncharacterized LOC101929574 Neighboring gene SH2 domain containing 4B Neighboring gene uncharacterized LOC105378387 Neighboring gene long intergenic non-protein coding RNA 2655

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11352

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
tetraspanin-enriched microdomain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetraspanin-14
Names
tetraspanin similar to TM4SF9
transmembrane 4 superfamily member 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128309.2NP_001121781.1  tetraspanin-14 isoform 2

    See identical proteins and their annotated locations for NP_001121781.1

    Status: VALIDATED

    Source sequence(s)
    AC021028, BM991301, BQ923322, DC300676
    Consensus CDS
    CCDS44448.1
    UniProtKB/Swiss-Prot
    Q8NG11
    Related
    ENSP00000418195.1, ENST00000481124.5
    Conserved Domains (1) summary
    cl02781
    Location:23110
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
  2. NM_001351266.1NP_001338195.1  tetraspanin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC021028, AL136638, BC002920, BM991301, BQ923322
    Consensus CDS
    CCDS7369.1
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family
  3. NM_001351267.3NP_001338196.1  tetraspanin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC021028
    Consensus CDS
    CCDS7369.1
    Related
    ENSP00000361231.1, ENST00000372158.6
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family
  4. NM_001351268.1NP_001338197.1  tetraspanin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC021028, AL136638, AL519790, BC002920, BM991301, BQ923322
    Consensus CDS
    CCDS7369.1
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family
  5. NM_001351269.1NP_001338198.1  tetraspanin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC021028, BC002920, BM991301, DN998010
    Consensus CDS
    CCDS7369.1
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family
  6. NM_001351270.1NP_001338199.1  tetraspanin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC021028, AL136638, BC002920, BM991301, BQ923322
    Consensus CDS
    CCDS7369.1
    Related
    ENSP00000361229.1, ENST00000372156.5
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family
  7. NM_001351271.1NP_001338200.1  tetraspanin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC021028, AL136638, BC002920, BM991301, BQ923322
    Consensus CDS
    CCDS7369.1
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family
  8. NM_001351272.1NP_001338201.1  tetraspanin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC021028, AL136638, BC002920, BM991301, BQ923322
    Consensus CDS
    CCDS7369.1
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family
  9. NM_030927.3NP_112189.2  tetraspanin-14 isoform 1

    See identical proteins and their annotated locations for NP_112189.2

    Status: VALIDATED

    Source sequence(s)
    AC021028, AL136638, BC002920, BM991301, BQ923322
    Consensus CDS
    CCDS7369.1
    UniProtKB/Swiss-Prot
    Q8NG11
    Related
    ENSP00000396270.2, ENST00000429989.7
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16257
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    80454265..80533124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540219.3XP_011538521.1  tetraspanin-14 isoform X1

    See identical proteins and their annotated locations for XP_011538521.1

    Conserved Domains (1) summary
    cd03159
    Location:127247
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. XM_017016712.2XP_016872201.1  tetraspanin-14 isoform X2

  3. XM_017016713.2XP_016872202.1  tetraspanin-14 isoform X2

    Related
    ENSP00000361230.2, ENST00000372157.6
  4. XM_024448212.1XP_024303980.1  tetraspanin-14 isoform X1

    Conserved Domains (1) summary
    cd03159
    Location:127247
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  5. XM_011540221.3XP_011538523.1  tetraspanin-14 isoform X1

    See identical proteins and their annotated locations for XP_011538523.1

    Conserved Domains (1) summary
    cd03159
    Location:127247
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  6. XM_011540220.3XP_011538522.1  tetraspanin-14 isoform X1

    See identical proteins and their annotated locations for XP_011538522.1

    Conserved Domains (1) summary
    cd03159
    Location:127247
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  7. XM_024448211.1XP_024303979.1  tetraspanin-14 isoform X1

    Conserved Domains (1) summary
    cd03159
    Location:127247
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_120662.1: Suppressed sequence

    Description
    NR_120662.1: This RefSeq was removed because the gene was discontinued.
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