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ACSBG2 acyl-CoA synthetase bubblegum family member 2 [ Homo sapiens (human) ]

Gene ID: 81616, updated on 5-Sep-2020

Summary

Official Symbol
ACSBG2provided by HGNC
Official Full Name
acyl-CoA synthetase bubblegum family member 2provided by HGNC
Primary source
HGNC:HGNC:24174
See related
Ensembl:ENSG00000130377 MIM:614363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BGR; BRGL; PRTDNY3; PRTD-NY3
Expression
Restricted expression toward testis (RPKM 79.4) See more
Orthologs

Genomic context

See ACSBG2 in Genome Data Viewer
Location:
19p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6135633..6193102)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6135654..6193113)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RANBP3 divergent transcript Neighboring gene regulatory factor X2 Neighboring gene ribosomal protein L32 pseudogene Neighboring gene uncharacterized LOC105372255 Neighboring gene MLLT1 super elongation complex subunit Neighboring gene alkaline ceramidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111089, DKFZp434K1635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CoA-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
acyl-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
arachidonate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase ACSBG2
Names
arachidonate--CoA ligase ACSBG2
bubblegum-related protein
testicular tissue protein Li 8
NP_001276106.1
NP_001276107.1
NP_001276108.1
NP_001276109.1
NP_001308313.1
NP_112186.3
XP_005259710.1
XP_011526631.1
XP_016882821.1
XP_016882822.1
XP_016882823.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289177.2NP_001276106.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

    See identical proteins and their annotated locations for NP_001276106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AK093433, AK302604, DB514968, HM005321, HY010944
    Consensus CDS
    CCDS12159.1
    UniProtKB/Swiss-Prot
    Q5FVE4
    UniProtKB/TrEMBL
    A0A140VJD4
    Related
    ENSP00000465589.1, ENST00000586696.5
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
  2. NM_001289178.2NP_001276107.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

    See identical proteins and their annotated locations for NP_001276107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AJ577571, AK093433, BC090046, HY011431
    Consensus CDS
    CCDS12159.1
    UniProtKB/Swiss-Prot
    Q5FVE4
    UniProtKB/TrEMBL
    A0A140VJD4
    Related
    ENSP00000467755.1, ENST00000591403.5
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
  3. NM_001289179.2NP_001276108.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to isoform 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK302604, DB514968, HM005321, HY010944
    UniProtKB/Swiss-Prot
    Q5FVE4
    UniProtKB/TrEMBL
    B4DYU1
    Conserved Domains (2) summary
    cd05933
    Location:73637
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:51638
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  4. NM_001289180.2NP_001276109.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AY009107, AY358766, DC399703, HM005321
    Consensus CDS
    CCDS74269.1
    UniProtKB/Swiss-Prot
    Q5FVE4
    Related
    ENSP00000466336.1, ENST00000588485.5
    Conserved Domains (1) summary
    cl17068
    Location:3478
    AFD_class_I; Adenylate forming domain, Class I superfamily
  5. NM_001321384.2NP_001308313.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AY358766, HM005321
    Consensus CDS
    CCDS82282.1
    UniProtKB/Swiss-Prot
    Q5FVE4
    Related
    ENSP00000464938.1, ENST00000588304.5
    Conserved Domains (2) summary
    cd05933
    Location:23615
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:1616
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  6. NM_030924.5NP_112186.3  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

    See identical proteins and their annotated locations for NP_112186.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK093433, BC090046, HY011431
    Consensus CDS
    CCDS12159.1
    UniProtKB/Swiss-Prot
    Q5FVE4
    UniProtKB/TrEMBL
    A0A140VJD4
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6135633..6193102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027333.1XP_016882822.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2

    Conserved Domains (2) summary
    cd05933
    Location:73642
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:51647
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  2. XM_017027334.1XP_016882823.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X3

    Conserved Domains (2) summary
    COG1022
    Location:51610
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    cl17068
    Location:73609
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. XM_005259653.3XP_005259710.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X4

    Conserved Domains (2) summary
    pfam00501
    Location:57519
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:73560
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. XM_017027332.2XP_016882821.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVE4
    UniProtKB/TrEMBL
    A0A140VJD4
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
  5. XM_011528329.1XP_011526631.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X5

    Related
    ENST00000591741.5
    Conserved Domains (1) summary
    cl17068
    Location:38458
    AFD_class_I; Adenylate forming domain, Class I superfamily
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