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ACSBG2 acyl-CoA synthetase bubblegum family member 2 [ Homo sapiens (human) ]

Gene ID: 81616, updated on 26-Oct-2022

Summary

Official Symbol
ACSBG2provided by HGNC
Official Full Name
acyl-CoA synthetase bubblegum family member 2provided by HGNC
Primary source
HGNC:HGNC:24174
See related
Ensembl:ENSG00000130377 MIM:614363; AllianceGenome:HGNC:24174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BGR; BRGL; PRTDNY3; PRTD-NY3
Summary
Enables acyl-CoA hydrolase activity and arachidonate-CoA ligase activity. Acts upstream of or within fatty acid metabolic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 79.4) See more
Orthologs
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Genomic context

See ACSBG2 in Genome Data Viewer
Location:
19p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6135633..6193091)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6124368..6181277)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6135644..6193102)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene regulatory factor X2 Neighboring gene Sharpr-MPRA regulatory region 343 Neighboring gene ribosomal protein L32 pseudogene Neighboring gene uncharacterized LOC105372255 Neighboring gene MLLT1 super elongation complex subunit Neighboring gene alkaline ceramidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111089, DKFZp434K1635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables CoA-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase ACSBG2
Names
arachidonate--CoA ligase ACSBG2
bubblegum-related protein
testicular tissue protein Li 8
NP_001276106.1
NP_001276107.1
NP_001276108.1
NP_001276109.1
NP_001308313.1
NP_112186.3
XP_005259710.1
XP_011526631.1
XP_016882821.1
XP_016882822.1
XP_047295433.1
XP_047295434.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289177.2NP_001276106.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

    See identical proteins and their annotated locations for NP_001276106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AK093433, AK302604, DB514968, HM005321, HY010944
    Consensus CDS
    CCDS12159.1
    UniProtKB/Swiss-Prot
    Q5FVE4, Q9H0C4
    UniProtKB/TrEMBL
    A0A140VJD4
    Related
    ENSP00000465589.1, ENST00000586696.5
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
  2. NM_001289178.2NP_001276107.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

    See identical proteins and their annotated locations for NP_001276107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AJ577571, AK093433, BC090046, HY011431
    Consensus CDS
    CCDS12159.1
    UniProtKB/Swiss-Prot
    Q5FVE4, Q9H0C4
    UniProtKB/TrEMBL
    A0A140VJD4
    Related
    ENSP00000467755.1, ENST00000591403.5
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
  3. NM_001289179.2NP_001276108.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to isoform 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK302604, DB514968, HM005321, HY010944
    Consensus CDS
    CCDS92498.1
    UniProtKB/Swiss-Prot
    Q5FVE4
    UniProtKB/TrEMBL
    A0A7P0Z4L8, B4DYU1
    Related
    ENSP00000506442.1, ENST00000681525.1
    Conserved Domains (2) summary
    cd05933
    Location:73637
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:51638
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  4. NM_001289180.2NP_001276109.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AY009107, AY358766, DC399703, HM005321
    UniProtKB/Swiss-Prot
    Q5FVE4
    Conserved Domains (1) summary
    cl17068
    Location:3478
    AFD_class_I; Adenylate forming domain, Class I superfamily
  5. NM_001321384.2NP_001308313.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AY358766, HM005321
    Consensus CDS
    CCDS82282.1
    UniProtKB/Swiss-Prot
    Q5FVE4
    Related
    ENSP00000464938.1, ENST00000588304.5
    Conserved Domains (2) summary
    cd05933
    Location:23615
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:1616
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  6. NM_030924.5NP_112186.3  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

    See identical proteins and their annotated locations for NP_112186.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK093433, BC090046, HY011431
    Consensus CDS
    CCDS12159.1
    UniProtKB/Swiss-Prot
    Q5FVE4, Q9H0C4
    UniProtKB/TrEMBL
    A0A140VJD4
    Related
    ENSP00000466336.2, ENST00000588485.6
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6135633..6193091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027333.2XP_016882822.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2

    Conserved Domains (2) summary
    cd05933
    Location:73642
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:51647
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  2. XM_047439477.1XP_047295433.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X3

  3. XM_005259653.4XP_005259710.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X4

    Conserved Domains (2) summary
    pfam00501
    Location:57519
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:73560
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. XM_017027332.3XP_016882821.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVE4, Q9H0C4
    UniProtKB/TrEMBL
    A0A140VJD4
    Conserved Domains (1) summary
    cd05933
    Location:73665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
  5. XM_047439478.1XP_047295434.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X5

  6. XM_011528329.2XP_011526631.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X6

    Conserved Domains (1) summary
    cl17068
    Location:38458
    AFD_class_I; Adenylate forming domain, Class I superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6124368..6181277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)