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FAM83D family with sequence similarity 83 member D [ Homo sapiens (human) ]

Gene ID: 81610, updated on 16-Aug-2021

Summary

Official Symbol
FAM83Dprovided by HGNC
Official Full Name
family with sequence similarity 83 member Dprovided by HGNC
Primary source
HGNC:HGNC:16122
See related
Ensembl:ENSG00000101447 MIM:618380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHICA; C20orf129; dJ616B8.3
Expression
Biased expression in esophagus (RPKM 30.9), urinary bladder (RPKM 8.3) and 13 other tissues See more
Orthologs
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Genomic context

See FAM83D in Genome Data Viewer
Location:
20q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (38926417..38953106)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37555060..37581749)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 173 Neighboring gene actin related protein 5 Neighboring gene protein phosphatase 1 regulatory subunit 16B Neighboring gene RNA, 7SL, cytoplasmic 116, pseudogene Neighboring gene DEAH-box helicase 35 Neighboring gene nucleophosmin 1 pseudogene 19 Neighboring gene Sharpr-MPRA regulatory region 15217

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38341

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell cycle G1/S phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to mitotic spindle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein FAM83D
Names
spindle protein CHICA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030919.3NP_112181.3  protein FAM83D

    Status: VALIDATED

    Source sequence(s)
    AK055793, AL023803, BC053683, BC080188
    Consensus CDS
    CCDS42872.2
    UniProtKB/Swiss-Prot
    Q9H4H8
    Related
    ENSP00000481465.1, ENST00000619850.2
    Conserved Domains (2) summary
    pfam13091
    Location:152287
    PLDc_2; PLD-like domain
    cl15239
    Location:21294
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    38926417..38953106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028088.1XP_016883577.1  protein FAM83D isoform X1

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