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COIL coilin [ Homo sapiens (human) ]

Gene ID: 8161, updated on 13-Mar-2020

Summary

Official Symbol
COILprovided by HGNC
Official Full Name
coilinprovided by HGNC
Primary source
HGNC:HGNC:2184
See related
Ensembl:ENSG00000121058 MIM:600272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLN80; p80-coilin
Summary
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues See more
Orthologs

Genomic context

See COIL in Genome Data Viewer
Location:
17q22
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (56938199..56961050, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55015560..55038411, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mouse mammary tumor virus receptor homolog 2 Neighboring gene tripartite motif containing 25 Neighboring gene microRNA 3614 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene Sharpr-MPRA regulatory region 7909 Neighboring gene uncharacterized LOC105371836 Neighboring gene serine carboxypeptidase 1 Neighboring gene ring finger protein 126 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coilin
Names
coilin p80
p80

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004645.3NP_004636.1  coilin

    See identical proteins and their annotated locations for NP_004636.1

    Status: REVIEWED

    Source sequence(s)
    AC004584, AW021880, BC010385
    Consensus CDS
    CCDS11592.1
    UniProtKB/Swiss-Prot
    P38432
    Related
    ENSP00000240316.4, ENST00000240316.5
    Conserved Domains (1) summary
    pfam15862
    Location:7138
    Coilin_N; Coilin N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    56938199..56961050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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