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NECTIN4 nectin cell adhesion molecule 4 [ Homo sapiens (human) ]

Gene ID: 81607, updated on 3-May-2020

Summary

Official Symbol
NECTIN4provided by HGNC
Official Full Name
nectin cell adhesion molecule 4provided by HGNC
Primary source
HGNC:HGNC:19688
See related
Ensembl:ENSG00000143217 MIM:609607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LNIR; PRR4; EDSS1; PVRL4; nectin-4
Summary
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
Expression
Biased expression in skin (RPKM 30.6), esophagus (RPKM 23.7) and 7 other tissues See more
Orthologs

Genomic context

See NECTIN4 in Genome Data Viewer
Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161070998..161089566, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161040781..161059385, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene upstream transcription factor 1 Neighboring gene Rho GTPase activating protein 30 Neighboring gene NECTIN4 antisense RNA 1 Neighboring gene kelch domain containing 9 Neighboring gene prefoldin subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686K05193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adherens junction organization TAS
Traceable Author Statement
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nectin-4
Names
Ig superfamily receptor LNIR
nectin 4
poliovirus receptor-related 4
poliovirus receptor-related protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028109.1 RefSeqGene

    Range
    5038..23598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030916.3NP_112178.2  nectin-4 precursor

    See identical proteins and their annotated locations for NP_112178.2

    Status: REVIEWED

    Source sequence(s)
    BC010423, BC013892, CF529301, DB223835
    Consensus CDS
    CCDS1216.1
    UniProtKB/Swiss-Prot
    Q96NY8
    UniProtKB/TrEMBL
    K4PZ75
    Related
    ENSP00000356991.3, ENST00000368012.4
    Conserved Domains (3) summary
    cd05888
    Location:46146
    Ig1_Nectin-4_like; Frst immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4, or as LNIR receptor) and similar proteins
    cd00096
    Location:266329
    Ig; Immunoglobulin domain
    cd07704
    Location:149242
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161070998..161089566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245508.3XP_005245565.1  nectin-4 isoform X3

    See identical proteins and their annotated locations for XP_005245565.1

    Conserved Domains (3) summary
    cd05888
    Location:46146
    Ig1_Nectin-4_like; Frst immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4, or as LNIR receptor) and similar proteins
    cd00096
    Location:266329
    Ig; Immunoglobulin domain
    cd07704
    Location:149242
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
  2. XM_011510022.2XP_011508324.1  nectin-4 isoform X2

    Conserved Domains (4) summary
    cd05888
    Location:46146
    Ig1_Nectin-4_like; Frst immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4, or as LNIR receptor) and similar proteins
    cd07704
    Location:149242
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
    smart00408
    Location:268320
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259332
    IG_like; Immunoglobulin like
  3. XM_011510021.2XP_011508323.1  nectin-4 isoform X1

    See identical proteins and their annotated locations for XP_011508323.1

    Conserved Domains (4) summary
    cd05888
    Location:46146
    Ig1_Nectin-4_like; Frst immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4, or as LNIR receptor) and similar proteins
    cd07704
    Location:149242
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
    smart00408
    Location:268320
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259332
    IG_like; Immunoglobulin like
  4. XM_011510023.1XP_011508325.1  nectin-4 isoform X4

    Conserved Domains (4) summary
    cd05888
    Location:46146
    Ig1_Nectin-4_like; Frst immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4, or as LNIR receptor) and similar proteins
    cd07704
    Location:149242
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
    smart00408
    Location:268320
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259332
    IG_like; Immunoglobulin like
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