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APK APS kinase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815963, updated on 19-Feb-2025
Official Symbol
APK
Official Full Name
APS kinase
Primary source
TAIR:AT2G14750
Locus tag
AT2G14750
See related
Araport:AT2G14750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ADENOSINE PHOSPHOSULFATE KINASE; ADENOSINE-5'-PHOSPHOSULFATE (APS) KINASE 1; AKN1; APK1; APS kinase; APS KINASE 1; ATAKN1; F26C24.11; F26C24_11
Summary
Encodes adenosine-5'-phosphosulfate kinase. Provides activated sulfate for sulfation of secondary metabolites, including the glucosinolates. Essential for pollen viability.
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Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (6313883..6316047)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene vacuolar sorting receptor 3 Neighboring gene Myb/SANT-like DNA-binding domain protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein

Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase. Ravilious GE, et al. J Biol Chem, 2012 Aug 31. PMID 22810229, Free PMC Article
  2. Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase. Ravilious GE, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22184237, Free PMC Article
  3. Molecular and catalytic properties of Arabidopsis thaliana adenylyl sulfate (APS)-kinase. Lillig CH, et al. Arch Biochem Biophys, 2001 Aug 15. PMID 11488606
  4. Adenosine-5'-phosphosulfate kinase is essential for Arabidopsis viability. Mugford SG, et al. FEBS Lett, 2010 Jan 4. PMID 19903478
  5. Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites. Mugford SG, et al. Plant Cell, 2009 Mar. PMID 19304933, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase.
    Title: Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase.
  2. The redox-sensitive APSK evolved after bifurcation of the sulfur assimilatory pathway in the green plant lineage.
    Title: Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase.
  3. Results indicate that the APK1 and APK2 isoforms of adenosine 5'-phosphosulfate kinase play a major role in the synthesis of secondary sulfated metabolites and are required for normal growth rates.
    Title: Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites.
Submit: New GeneRIF Correction
NM_127039.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenylylsulfate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within male gamete generation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of glucosinolate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sulfate assimilation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in plastid TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
APS kinase
NP_179082.1
  • APS kinase (APK); CONTAINS InterPro DOMAIN/s: Adenylylsulphate kinase, C-terminal (InterPro:IPR002891); BEST Arabidopsis thaliana protein match is: APS-kinase 2 (TAIR:AT4G39940.1); Has 5042 Blast hits to 5042 proteins in 1485 species: Archae - 54; Bacteria - 2991; Metazoa - 244; Fungi - 284; Plants - 130; Viruses - 2; Other Eukaryotes - 1337 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    6313883..6316047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127039.4 → NP_179082.1  APS kinase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179082.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q43295, Q8LES2
    UniProtKB/TrEMBL
    A0A178VLM3, A0A7G2E694
    Conserved Domains (1) summary
    COG0529
    Location:79 → 275
    CysC; Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q43295.1

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