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GFOD2 glucose-fructose oxidoreductase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 81577, updated on 7-Dec-2018

Summary

Official Symbol
GFOD2provided by HGNC
Official Full Name
glucose-fructose oxidoreductase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28159
See related
Ensembl:ENSG00000141098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in esophagus (RPKM 4.4), brain (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See GFOD2 in Genome Data Viewer
Location:
16q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (67674533..67719370, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67708436..67753273, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene par-6 family cell polarity regulator alpha Neighboring gene chromosome 16 open reading frame 86 Neighboring gene enkurin domain containing 1 Neighboring gene RAN binding protein 10 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23802, FLJ39316, MGC11335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glucose-fructose oxidoreductase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243650.1NP_001230579.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an unspliced coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010530, AK096635, BQ003788, BQ437486, DC368734, DC381447
    Consensus CDS
    CCDS59268.1
    UniProtKB/Swiss-Prot
    Q3B7J2
    Related
    ENSP00000478260.1, ENST00000602279.2
    Conserved Domains (1) summary
    cl21454
    Location:786
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_030819.4NP_110446.3  glucose-fructose oxidoreductase domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_110446.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK225997, BC000757
    Consensus CDS
    CCDS10845.1
    UniProtKB/Swiss-Prot
    Q3B7J2
    Related
    ENSP00000268797.7, ENST00000268797.11
    Conserved Domains (1) summary
    COG0673
    Location:1364
    MviM; Predicted dehydrogenase [General function prediction only]

RNA

  1. NR_027398.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of multiple upstream ORFs that are predicted to interfere with translation of the longest ORF; translation of these upstream ORFs renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC000757, BI826603

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    67674533..67719370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721288.4XP_006721351.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006721351.1

    UniProtKB/Swiss-Prot
    Q3B7J2
    Conserved Domains (1) summary
    COG0673
    Location:15259
    MviM; Predicted dehydrogenase [General function prediction only]
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