Format

Send to:

Choose Destination

LMAN2L lectin, mannose binding 2 like [ Homo sapiens (human) ]

Gene ID: 81562, updated on 11-Sep-2019

Summary

Official Symbol
LMAN2Lprovided by HGNC
Official Full Name
lectin, mannose binding 2 likeprovided by HGNC
Primary source
HGNC:HGNC:19263
See related
Ensembl:ENSG00000114988 MIM:609552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VIPL; MRT52
Summary
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in ovary (RPKM 11.7), thyroid (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See LMAN2L in Genome Data Viewer
Location:
2q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96705929..96740092, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97371666..97405813, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene fer-1 like family member 5 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4 Neighboring gene microRNA 3127 Neighboring gene CNNM3 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mental retardation, autosomal recessive 52
MedGen: C4225168 OMIM: 616887 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Pathways from BioSystems

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem (from REACTOME)
    COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystemCOPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles wer...
  • Cargo concentration in the ER, organism-specific biosystem (from REACTOME)
    Cargo concentration in the ER, organism-specific biosystemComputational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, wh...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11139, DKFZp564L2423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannose binding TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding NAS
Non-traceable Author Statement
more info
PubMed 
protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COPII-coated ER to Golgi transport vesicle NAS
Non-traceable Author Statement
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
VIP36-like protein
Names
LMAN2-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046866.1 RefSeqGene

    Range
    4991..39154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142292.1NP_001135764.1  VIP36-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001135764.1

    Status: REVIEWED

    Source sequence(s)
    AK310100, BX648002
    Consensus CDS
    CCDS46365.1
    UniProtKB/Swiss-Prot
    Q9H0V9
    Related
    ENSP00000366280.4, ENST00000377079.8
    Conserved Domains (1) summary
    cl14058
    Location:50309
    lectin_L-type; legume lectins
  2. NM_001322346.1NP_001309275.1  VIP36-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK299740, AK310100, BC000347
    UniProtKB/Swiss-Prot
    Q9H0V9
    Conserved Domains (1) summary
    cl14058
    Location:35164
    lectin_L-type; legume lectins
  3. NM_001322347.1NP_001309276.1  VIP36-like protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK295463, AK310100, BC000347
    UniProtKB/Swiss-Prot
    Q9H0V9
    UniProtKB/TrEMBL
    B4DI83
    Conserved Domains (1) summary
    cl14058
    Location:1171
    lectin_L-type; legume lectins
  4. NM_001322350.1NP_001309279.1  VIP36-like protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK304515, AK310100, BC000347
    UniProtKB/Swiss-Prot
    Q9H0V9
    UniProtKB/TrEMBL
    B4E308
    Conserved Domains (1) summary
    cl14058
    Location:1160
    lectin_L-type; legume lectins
  5. NM_001322351.1NP_001309280.1  VIP36-like protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK301077, AK310100, BC000347
    UniProtKB/Swiss-Prot
    Q9H0V9
    UniProtKB/TrEMBL
    B4DVH1
    Conserved Domains (1) summary
    cl14058
    Location:21153
    lectin_L-type; legume lectins
  6. NM_001322352.1NP_001309281.1  VIP36-like protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC068539, BC004505
    UniProtKB/TrEMBL
    B4DI83
    Conserved Domains (1) summary
    cl14058
    Location:1171
    lectin_L-type; legume lectins
  7. NM_001322354.1NP_001309283.1  VIP36-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC068539, AK310100, BC004505, DA521101, DC354352
    UniProtKB/Swiss-Prot
    Q9H0V9
    Conserved Domains (1) summary
    cl14058
    Location:35164
    lectin_L-type; legume lectins
  8. NM_001322355.1NP_001309284.1  VIP36-like protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068539, BC004505
    UniProtKB/TrEMBL
    B4DVH1
    Conserved Domains (1) summary
    cl14058
    Location:21153
    lectin_L-type; legume lectins
  9. NM_001322356.1NP_001309285.1  VIP36-like protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068539, AK310100, AK316331, BC004505
    UniProtKB/TrEMBL
    B4DVH1
    Conserved Domains (1) summary
    cl14058
    Location:21153
    lectin_L-type; legume lectins
  10. NM_030805.3NP_110432.1  VIP36-like protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_110432.1

    Status: REVIEWED

    Source sequence(s)
    AK310100, BC000347
    Consensus CDS
    CCDS2023.1
    UniProtKB/Swiss-Prot
    Q9H0V9
    Related
    ENSP00000264963.4, ENST00000264963.8
    Conserved Domains (1) summary
    cl14058
    Location:50298
    lectin_L-type; legume lectins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96705929..96740092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453167.1XP_024308935.1  VIP36-like protein isoform X1

    Conserved Domains (1) summary
    cl14058
    Location:1160
    lectin_L-type; legume lectins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024518.1: Suppressed sequence

    Description
    NR_024518.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
  2. NR_024519.1: Suppressed sequence

    Description
    NR_024519.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
  3. NR_024520.1: Suppressed sequence

    Description
    NR_024520.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
  4. NR_024521.1: Suppressed sequence

    Description
    NR_024521.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
Support Center