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TRIM11 tripartite motif containing 11 [ Homo sapiens (human) ]

Gene ID: 81559, updated on 4-May-2020

Summary

Official Symbol
TRIM11provided by HGNC
Official Full Name
tripartite motif containing 11provided by HGNC
Primary source
HGNC:HGNC:16281
See related
Ensembl:ENSG00000154370 MIM:607868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIA1; RNF92
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See TRIM11 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228393672..228406835, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228581373..228594584, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene Sharpr-MPRA regulatory region 4086 Neighboring gene uncharacterized LOC101927401 Neighboring gene microRNA 6742 Neighboring gene tripartite motif containing 17 Neighboring gene H3.4 histone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 infection is modestly restricted by human TRIM11 and downregulation of TRIM11 enhances virus release, suggesting the interaction between HIV-1 Gag and TRIM11 PubMed
Vpr vpr HIV-1 Vpr may indirectly regulate TRIM11 in a dose-dependent manner, which is independent of the ubiquitin system or VprBP-mediated pathway PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral release from host cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral release from host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM11
Names
RING finger protein 92
RING-type E3 ubiquitin transferase TRIM11
tripartite motif-containing protein 11
NP_660215.1
XP_011542587.1
XP_016857901.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145214.3NP_660215.1  E3 ubiquitin-protein ligase TRIM11

    See identical proteins and their annotated locations for NP_660215.1

    Status: REVIEWED

    Source sequence(s)
    AL670729
    Consensus CDS
    CCDS31048.1
    UniProtKB/Swiss-Prot
    Q96F44
    Related
    ENSP00000284551.6, ENST00000284551.11
    Conserved Domains (3) summary
    cd15811
    Location:288456
    SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
    pfam00643
    Location:87128
    zf-B_box; B-box zinc finger
    cd16594
    Location:1357
    RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228393672..228406835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544285.3XP_011542587.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

    Conserved Domains (3) summary
    pfam00643
    Location:87128
    zf-B_box; B-box zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15811
    Location:211379
    SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
  2. XM_017002412.2XP_016857901.1  E3 ubiquitin-protein ligase TRIM11 isoform X1

    UniProtKB/Swiss-Prot
    Q96F44
    Conserved Domains (3) summary
    pfam00643
    Location:87128
    zf-B_box; B-box zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15811
    Location:287455
    SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
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