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CYRIA CYFIP related Rac1 interactor A [ Homo sapiens (human) ]

Gene ID: 81553, updated on 13-May-2022

Summary

Official Symbol
CYRIAprovided by HGNC
Official Full Name
CYFIP related Rac1 interactor Aprovided by HGNC
Primary source
HGNC:HGNC:25373
See related
Ensembl:ENSG00000197872 AllianceGenome:HGNC:25373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYRI-A; FAM49A
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 30.2), thyroid (RPKM 23.9) and 18 other tissues See more
Orthologs
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Genomic context

See CYRIA in Genome Data Viewer
Location:
2p24.2
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (16549459..16665834, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (16581160..16697534, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (16730727..16847102, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373444 Neighboring gene Sharpr-MPRA regulatory region 232 Neighboring gene long intergenic non-protein coding RNA 1866 Neighboring gene RN7SK pseudogene 168

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of family with sequence similarity 49, member A (FAM49A) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11080, FLJ33961, DKFZp566A1524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CYFIP-related Rac1 interactor A
Names
family with sequence similarity 49 member A
protein FAM49A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030797.4NP_110424.1  CYFIP-related Rac1 interactor A

    See identical proteins and their annotated locations for NP_110424.1

    Status: VALIDATED

    Source sequence(s)
    AC104623, BC038971, DA188616
    Consensus CDS
    CCDS1688.1
    UniProtKB/Swiss-Prot
    Q9H0Q0
    Related
    ENSP00000370724.3, ENST00000381323.7
    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    16549459..16665834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453163.2XP_024308931.1  CYFIP-related Rac1 interactor A isoform X1

    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
  2. XM_047445942.1XP_047301898.1  CYFIP-related Rac1 interactor A isoform X1

  3. XM_024453166.2XP_024308934.1  CYFIP-related Rac1 interactor A isoform X1

    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
  4. XM_047445943.1XP_047301899.1  CYFIP-related Rac1 interactor A isoform X1

  5. XM_047445941.1XP_047301897.1  CYFIP-related Rac1 interactor A isoform X1

    Related
    ENSP00000384771.1, ENST00000406434.5
  6. XM_047445940.1XP_047301896.1  CYFIP-related Rac1 interactor A isoform X1

  7. XM_047445939.1XP_047301895.1  CYFIP-related Rac1 interactor A isoform X1

  8. XM_047445945.1XP_047301901.1  CYFIP-related Rac1 interactor A isoform X1

  9. XM_047445944.1XP_047301900.1  CYFIP-related Rac1 interactor A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    16581160..16697534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)