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CYRIA CYFIP related Rac1 interactor A [ Homo sapiens (human) ]

Gene ID: 81553, updated on 1-Jun-2020

Summary

Official Symbol
CYRIAprovided by HGNC
Official Full Name
CYFIP related Rac1 interactor Aprovided by HGNC
Primary source
HGNC:HGNC:25373
See related
Ensembl:ENSG00000197872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYRI-A; FAM49A
Expression
Broad expression in brain (RPKM 30.2), thyroid (RPKM 23.9) and 18 other tissues See more
Orthologs

Genomic context

See CYRIA in Genome Data Viewer
Location:
2p24.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (16549459..16665834, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (16730727..16847134, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985855 Neighboring gene uncharacterized LOC105373444 Neighboring gene long intergenic non-protein coding RNA 1866 Neighboring gene RN7SK pseudogene 168

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of family with sequence similarity 49, member A (FAM49A) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11080, FLJ33961, DKFZp566A1524

Gene Ontology Provided by GOA

Component Evidence Code Pubs
intracellular IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
CYFIP-related Rac1 interactor A
Names
family with sequence similarity 49 member A
protein FAM49A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030797.4NP_110424.1  CYFIP-related Rac1 interactor A

    See identical proteins and their annotated locations for NP_110424.1

    Status: VALIDATED

    Source sequence(s)
    AC104623, BC038971, DA188616
    Consensus CDS
    CCDS1688.1
    UniProtKB/Swiss-Prot
    Q9H0Q0
    Related
    ENSP00000370724.3, ENST00000381323.7
    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    16549459..16665834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453164.1XP_024308932.1  CYFIP-related Rac1 interactor A isoform X1

    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
  2. XM_024453166.1XP_024308934.1  CYFIP-related Rac1 interactor A isoform X1

    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
  3. XM_024453163.1XP_024308931.1  CYFIP-related Rac1 interactor A isoform X1

    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
  4. XM_024453165.1XP_024308933.1  CYFIP-related Rac1 interactor A isoform X1

    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
  5. XM_006712108.4XP_006712171.1  CYFIP-related Rac1 interactor A isoform X1

    See identical proteins and their annotated locations for XP_006712171.1

    UniProtKB/Swiss-Prot
    Q9H0Q0
    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
  6. XM_005262630.4XP_005262687.1  CYFIP-related Rac1 interactor A isoform X1

    See identical proteins and their annotated locations for XP_005262687.1

    UniProtKB/Swiss-Prot
    Q9H0Q0
    Conserved Domains (1) summary
    pfam07159
    Location:17319
    DUF1394; Protein of unknown function (DUF1394)
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