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VOPP1 VOPP1 WW domain binding protein [ Homo sapiens (human) ]

Gene ID: 81552, updated on 22-Sep-2022

Summary

Official Symbol
VOPP1provided by HGNC
Official Full Name
VOPP1 WW domain binding proteinprovided by HGNC
Primary source
HGNC:HGNC:34518
See related
Ensembl:ENSG00000154978 MIM:611915; AllianceGenome:HGNC:34518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECOP; GASP; WBP1L2
Summary
Located in cytoplasmic vesicle membrane and endosome. Is integral component of organelle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 19.1), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

See VOPP1 in Genome Data Viewer
Location:
7p11.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (55434964..55572502, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (55630918..55732784, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (55538301..55640195, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA exonuclease 1 homolog Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene Sharpr-MPRA regulatory region 1113 Neighboring gene VOPP1 divergent transcript Neighboring gene cell division cycle 42 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20532, DKFZp564K0822

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 
is_active_in organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vesicular, overexpressed in cancer, prosurvival protein 1
Names
EGFR-coamplified and overexpressed protein
Glioblastoma-amplified secreted protein
VOPP1, WBP1/VOPP1 family member
hypothetical protein DKFZp564K0822
putative NF-kappa-B-activating protein 055N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284282.2NP_001271211.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001271211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC073347, AK309288, HY076549
    Consensus CDS
    CCDS64656.1
    UniProtKB/Swiss-Prot
    Q96AW1
    Related
    ENSP00000393210.1, ENST00000418904.5
    Conserved Domains (1) summary
    cl28929
    Location:88146
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
  2. NM_001284283.2NP_001271212.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001271212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC073347, AK315882, DA814621, HY076549
    Consensus CDS
    CCDS64655.1
    UniProtKB/Swiss-Prot
    Q96AW1
    Related
    ENSP00000486983.1, ENST00000625836.2
    Conserved Domains (1) summary
    PRK13729
    Location:102160
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
  3. NM_001284284.1NP_001271213.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001271213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC073347, AK092992, HY073578, HY076549
    Consensus CDS
    CCDS64654.1
    UniProtKB/Swiss-Prot
    Q96AW1
    Related
    ENSP00000415230.1, ENST00000433959.5
    Conserved Domains (1) summary
    pfam06679
    Location:81124
    DUF1180; Protein of unknown function (DUF1180)
  4. NM_001321242.1NP_001308171.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073237, AC073347, DA991268, HY076549
  5. NM_001321243.2NP_001308172.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC073347, DB475432, HY057980, HY076549
  6. NM_001321244.2NP_001308173.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC073347, AC099681, DA732543, DB496308, HY076549
    Consensus CDS
    CCDS83187.1
    UniProtKB/TrEMBL
    C9JVH1
    Related
    ENSP00000407356.1, ENST00000427700.1
    Conserved Domains (1) summary
    PRK13729
    Location:103161
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
  7. NM_001321246.2NP_001308175.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC073347, DA257111, DB475432, HY076549
    Conserved Domains (1) summary
    PRK13729
    Location:79137
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
  8. NM_001321247.2NP_001308176.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC073347, BI597655, DB475432, HY076549
  9. NM_001321248.2NP_001308177.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC073347, DA530391, HY076549
    Consensus CDS
    CCDS83186.1
    UniProtKB/TrEMBL
    C9J827
    Related
    ENSP00000411447.1, ENST00000454227.5
    Conserved Domains (1) summary
    PRK13729
    Location:42100
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
  10. NM_001321249.2NP_001308178.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 11 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
    Source sequence(s)
    AC073347, HY032103, HY076549
    UniProtKB/Swiss-Prot
    Q96AW1
    UniProtKB/TrEMBL
    A0A024QYZ2
  11. NM_001321250.2NP_001308179.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 11 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
    Source sequence(s)
    AC073347, AK090825, HY076549
    UniProtKB/Swiss-Prot
    Q96AW1
    UniProtKB/TrEMBL
    A0A024QYZ2
  12. NM_001321251.1NP_001308180.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 11 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
    Source sequence(s)
    AC073237, AC073347, DA772419, HY076549
    UniProtKB/Swiss-Prot
    Q96AW1
    UniProtKB/TrEMBL
    A0A024QYZ2
  13. NM_030796.5NP_110423.3  vesicular, overexpressed in cancer, prosurvival protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_110423.3

    Status: VALIDATED

    Source sequence(s)
    AC073347, AK225755, DB496308, HY076549
    Consensus CDS
    CCDS47588.1
    UniProtKB/Swiss-Prot
    Q96AW1, Q9H0W4
    Related
    ENSP00000285279.5, ENST00000285279.10
    Conserved Domains (1) summary
    cl28929
    Location:105163
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    55434964..55572502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515539.2XP_011513841.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform X1

  2. XM_011515546.3XP_011513848.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform X4

  3. XM_011515540.3XP_011513842.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform X2

  4. XM_011515541.3XP_011513843.1  vesicular, overexpressed in cancer, prosurvival protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    55630918..55732784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)