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TDRD3 tudor domain containing 3 [ Homo sapiens (human) ]

Gene ID: 81550, updated on 8-Jul-2018
Official Symbol
TDRD3provided by HGNC
Official Full Name
tudor domain containing 3provided by HGNC
Primary source
HGNC:HGNC:20612
See related
Ensembl:ENSG00000083544 MIM:614392; Vega:OTTHUMG00000017007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 6.2), thyroid (RPKM 5.5) and 25 other tissues See more
Orthologs
See TDRD3 in Genome Data Viewer
Location:
13q21.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (60396457..60573879)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (60970591..61148013)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene TAR DNA binding protein pseudogene 2 Neighboring gene uncharacterized LOC105370228 Neighboring gene uncharacterized LOC105370230 Neighboring gene RNA, 5S ribosomal pseudogene 31

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

NHGRI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ21007

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
colocalizes_with exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tudor domain-containing protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146070.1NP_001139542.1  tudor domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001139542.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BG219444, DA440035, EU643838
    Consensus CDS
    CCDS53872.1
    UniProtKB/Swiss-Prot
    Q9H7E2
    Related
    ENSP00000440190.1, ENST00000535286.5
    Conserved Domains (3) summary
    cd04508
    Location:652700
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:287325
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam08585
    Location:41162
    RMI1_N; RecQ mediated genome instability protein
  2. NM_001146071.1NP_001139543.1  tudor domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001139543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and uses two different splice sites in its UTRs, compared to variant 1. These differences cause translation initiation at a downstream start codon. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BG219444, BX537910
    Consensus CDS
    CCDS9441.1
    UniProtKB/Swiss-Prot
    Q9H7E2
    UniProtKB/TrEMBL
    A0A024QZE0
    Related
    ENSP00000196169.3, ENST00000196169.7
    Conserved Domains (4) summary
    cd04508
    Location:559607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:194232
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam06003
    Location:523647
    SMN; Survival motor neuron protein (SMN)
    pfam08585
    Location:172
    RMI1_N; RecQ mediated genome instability protein
  3. NM_030794.2NP_110421.1  tudor domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_110421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and uses a different splice site in its 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream start codon. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA004370, AK024660, BG191408, BX537910
    Consensus CDS
    CCDS9441.1
    UniProtKB/Swiss-Prot
    Q9H7E2
    UniProtKB/TrEMBL
    A0A024QZE0
    Related
    ENSP00000367126.2, OTTHUMP00000018483, ENST00000377894.6, OTTHUMT00000045173
    Conserved Domains (4) summary
    cd04508
    Location:559607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:194232
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam06003
    Location:523647
    SMN; Survival motor neuron protein (SMN)
    pfam08585
    Location:172
    RMI1_N; RecQ mediated genome instability protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    60396457..60573879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449417.1XP_024305185.1  tudor domain-containing protein 3 isoform X4

    Conserved Domains (3) summary
    cd04508
    Location:559607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:194232
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam08585
    Location:172
    RMI1_N; RecQ mediated genome instability protein
  2. XM_024449419.1XP_024305187.1  tudor domain-containing protein 3 isoform X5

    Related
    ENSP00000367113.1, ENST00000377881.6
    Conserved Domains (4) summary
    cd04508
    Location:559607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:194232
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam06003
    Location:523647
    SMN; Survival motor neuron protein (SMN)
    pfam08585
    Location:172
    RMI1_N; RecQ mediated genome instability protein
  3. XM_005266560.2XP_005266617.1  tudor domain-containing protein 3 isoform X4

    Conserved Domains (3) summary
    cd04508
    Location:559607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:194232
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam08585
    Location:172
    RMI1_N; RecQ mediated genome instability protein
  4. XM_024449418.1XP_024305186.1  tudor domain-containing protein 3 isoform X5

    Related
    ENSP00000477993.1, ENST00000621840.4
    Conserved Domains (4) summary
    cd04508
    Location:559607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:194232
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam06003
    Location:523647
    SMN; Survival motor neuron protein (SMN)
    pfam08585
    Location:172
    RMI1_N; RecQ mediated genome instability protein
  5. XM_005266556.4XP_005266613.1  tudor domain-containing protein 3 isoform X2

    Conserved Domains (3) summary
    cd04508
    Location:652700
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:287325
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam08585
    Location:41162
    RMI1_N; RecQ mediated genome instability protein
  6. XM_017020777.1XP_016876266.1  tudor domain-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    Q9H7E2
    Conserved Domains (3) summary
    cd04508
    Location:652700
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:287325
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam08585
    Location:41162
    RMI1_N; RecQ mediated genome instability protein
  7. XM_024449416.1XP_024305184.1  tudor domain-containing protein 3 isoform X1

    Conserved Domains (3) summary
    cd04508
    Location:559607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd14282
    Location:194232
    UBA_TDRD3; UBA domain of Tudor domain-containing protein 3 (TDRD3) and similar proteins
    pfam08585
    Location:172
    RMI1_N; RecQ mediated genome instability protein

RNA

  1. XR_002957475.1 RNA Sequence

  2. XR_002957476.1 RNA Sequence

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