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LRRC3 leucine rich repeat containing 3 [ Homo sapiens (human) ]

Gene ID: 81543, updated on 22-Sep-2022

Summary

Official Symbol
LRRC3provided by HGNC
Official Full Name
leucine rich repeat containing 3provided by HGNC
Primary source
HGNC:HGNC:14965
See related
Ensembl:ENSG00000160233 MIM:617620; AllianceGenome:HGNC:14965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC3DN; C21orf30; C21orf102
Summary
Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 2.2), ovary (RPKM 1.8) and 24 other tissues See more
Orthologs
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Genomic context

See LRRC3 in Genome Data Viewer
Location:
21q22.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44455510..44462196)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42815963..42822649)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45875393..45882079)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily M member 2 Neighboring gene Z6 small nucleolar RNA Neighboring gene LRRC3 divergent transcript Neighboring gene MT-CYB pseudogene 21 Neighboring gene MT-ND6 pseudogene 21 Neighboring gene MT-ND5 pseudogene 1 Neighboring gene hepatocellular carcinoma ferroptosis associative lncRNA

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434C128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 3
Names
LRRC3 downstream neighbor (non-protein coding)
intronless long ORF, AL117578

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030891.6NP_112153.1  leucine-rich repeat-containing protein 3 precursor

    See identical proteins and their annotated locations for NP_112153.1

    Status: VALIDATED

    Source sequence(s)
    AK127604, AL117578, AP001065, BC064321
    Consensus CDS
    CCDS13711.1
    UniProtKB/Swiss-Prot
    Q0VDJ2, Q9BY71
    Related
    ENSP00000291592.4, ENST00000291592.6
    Conserved Domains (4) summary
    smart00013
    Location:3268
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:4865
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:89129
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44455510..44462196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42815963..42822649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)