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TMX1 thioredoxin related transmembrane protein 1 [ Homo sapiens (human) ]

Gene ID: 81542, updated on 11-Sep-2019

Summary

Official Symbol
TMX1provided by HGNC
Official Full Name
thioredoxin related transmembrane protein 1provided by HGNC
Primary source
HGNC:HGNC:15487
See related
Ensembl:ENSG00000139921 MIM:610527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMX; TXNDC; PDIA11; TXNDC1
Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in urinary bladder (RPKM 15.6), colon (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See TMX1 in Genome Data Viewer
Location:
14q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (51240247..51257655)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (51706886..51724373)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370492 Neighboring gene uncharacterized LOC400212 Neighboring gene tripartite motif containing 9 Neighboring gene long intergenic non-protein coding RNA 519 Neighboring gene uncharacterized LOC105370495 Neighboring gene long intergenic non-protein coding RNA 640

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TMX1; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564E1962

Gene Ontology Provided by GOA

Function Evidence Code Pubs
disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thioredoxin-related transmembrane protein 1
Names
protein disulfide isomerase family A, member 11
thioredoxin domain containing 1
thioredoxin domain-containing protein 1
transmembrane Trx-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030755.5NP_110382.3  thioredoxin-related transmembrane protein 1 precursor

    See identical proteins and their annotated locations for NP_110382.3

    Status: VALIDATED

    Source sequence(s)
    AB048246, AL591807, BC056874, BU754378
    Consensus CDS
    CCDS41953.1
    UniProtKB/Swiss-Prot
    Q9H3N1
    Related
    ENSP00000393316.2, ENST00000457354.7
    Conserved Domains (1) summary
    cd02994
    Location:29129
    PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    51240247..51257655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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