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ITFG1 integrin alpha FG-GAP repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 81533, updated on 21-Dec-2019

Summary

Official Symbol
ITFG1provided by HGNC
Official Full Name
integrin alpha FG-GAP repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:30697
See related
Ensembl:ENSG00000129636 MIM:611803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP; CDA08; LNKN-1; 2310047C21Rik
Expression
Ubiquitous expression in brain (RPKM 35.9), adrenal (RPKM 25.7) and 25 other tissues See more
Orthologs

Genomic context

See ITFG1 in Genome Data Viewer
Location:
16q12.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (47154387..47461274, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (47188302..47495018, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene neuropilin and tolloid like 2 Neighboring gene ITFG1 antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 72 Neighboring gene proteasome 20S subunit beta 5 pseudogene Neighboring gene uncharacterized LOC101927080 Neighboring gene RNA, 5S ribosomal pseudogene 424 Neighboring gene Sharpr-MPRA regulatory region 10524 Neighboring gene phosphorylase kinase regulatory subunit beta Neighboring gene RNA, 5S ribosomal pseudogene 425

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
T-cell immunomodulatory protein
Names
LINKIN
integrin-alpha FG-GAP repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305002.1NP_001291931.1  T-cell immunomodulatory protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR, lacks part of the 5' coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. These differences result in the use of a downstream in-frame start codon and a frameshift in the 3' coding region. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK301908, BC024162, BM680211, DA285856, EL948664
    Consensus CDS
    CCDS76862.1
    UniProtKB/Swiss-Prot
    Q8TB96
    UniProtKB/TrEMBL
    B4DXC2, F5GXC5
    Related
    ENSP00000441062.2, ENST00000544001.6
    Conserved Domains (1) summary
    pfam13517
    Location:153236
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
  2. NM_030790.5NP_110417.2  T-cell immunomodulatory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_110417.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC024162, BM680211, EL948664
    Consensus CDS
    CCDS10728.1
    UniProtKB/Swiss-Prot
    Q8TB96
    Related
    ENSP00000319918.6, ENST00000320640.11
    Conserved Domains (1) summary
    pfam13517
    Location:55118
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    47154387..47461274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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