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Ogg1 8-oxoguanine DNA glycosylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81528, updated on 27-Nov-2024

Summary

Official Symbol
Ogg1provided by RGD
Official Full Name
8-oxoguanine DNA glycosylaseprovided by RGD
Primary source
RGD:621168
See related
EnsemblRapid:ENSRNOG00000052140 AllianceGenome:RGD:621168
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables damaged DNA binding activity and oxidized purine nucleobase lesion DNA N-glycosylase activity. Involved in several processes, including cellular response to cadmium ion; response to estradiol; and response to folic acid. Predicted to be located in mitochondrion; nuclear matrix; and nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Biomarker of hepatitis; middle cerebral artery infarction; renal cell carcinoma; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 105.3), Spleen (RPKM 79.7) and 9 other tissues See more
Orthologs
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Genomic context

See Ogg1 in Genome Data Viewer
Location:
4q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148030237..148037599)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146474701..146481959)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145282828..145289367)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene copine family member 9 Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing TCP1 subunit 3, pseudogene 6 Neighboring gene gamma-glutamylamine cyclotransferase, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within base-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of double-strand break repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to folic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-glycosylase/DNA lyase
Names
8-oxoguanine DNA-glycosylase 1
NP_110497.1
XP_017448395.1
XP_038964348.1
XP_063142814.1
XP_063142815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030870.1NP_110497.1  N-glycosylase/DNA lyase

    See identical proteins and their annotated locations for NP_110497.1

    Status: PROVISIONAL

    Source sequence(s)
    AF029690
    UniProtKB/Swiss-Prot
    O70249
    UniProtKB/TrEMBL
    A6IBQ2
    Related
    ENSRNOP00000070483.1, ENSRNOT00000085766.3
    Conserved Domains (1) summary
    TIGR00588
    Location:11325
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    148030237..148037599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286745.1XP_063142815.1  N-glycosylase/DNA lyase isoform X4

  2. XM_063286744.1XP_063142814.1  N-glycosylase/DNA lyase isoform X2

  3. XM_039108420.2XP_038964348.1  N-glycosylase/DNA lyase isoform X3

    Conserved Domains (1) summary
    TIGR00588
    Location:1168
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
  4. XM_017592906.3XP_017448395.1  N-glycosylase/DNA lyase isoform X1