Nrp2 neuropilin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nrp2provided by RGD
Official Full Name: neuropilin 2provided by RGD
Primary source: RGD:621442
See related: Ensembl:ENSRNOG00000031232 AllianceGenome:RGD:621442
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and semaphorin receptor activity. Involved in axon guidance. Predicted to be located in axon. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic membrane. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 127.6), Heart (RPKM 80.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (64122815..64238007)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (69496875..69609802)

Chromosome 9 - NC_051344.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy.
Title: Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy.
VEGF-C/NRP-2 may mediate autophagy by regulating the phosphorylation of 4EBP1 and P70S6K; VEGF-C treatment may be identified as a therapeutic target in renal injury repair due to its capacity to promote tubular cell survival in the future
Title: Roles for VEGF-C/NRP-2 axis in regulating renal tubular epithelial cell survival and autophagy during serum deprivation.
important role in the regulation of neointimal hyperplasia by modulating vascular smooth muscle cell migration and proliferation
Title: Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury.
the novel interplay between PAX8 and Neuropilin-2
Title: Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells.
Major endogenous forms of immunoreactive-NERPs in brain and gastrointetinal tract are identified as NERP-1, NERP-2, and big NERP-2 (NERP-1 + NERP-2), with NERP-1 and big NERP-2 being predominant.
Title: Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.
NRP2 is necessary to trigger Sema3A-induced glioma cell repulsion and attraction.
Title: Neuropilin-2 acts as a modulator of Sema3A-dependent glioma cell migration.
upregulated in bladder with chronic cyclophosphamide-induced cystitis
Title: Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors (VEGFR-2, Npn-1, and Npn-2) in rats with cyclophosphamide-induced cystitis.
in cultured rat Schwann cells, expression of mRNA encoding neuropilin-2 (NRP2) and plexin-A3 (PlexA3), proteins involved in semaphorin-3F (Sema3F) signal transduction, is diminished markedly by forskolin
Title: Schwann cell-autonomous role of neuropilin-2.
Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system.
Title: Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons.
neuropilin-2 is overexpressed in the rat brain after limbic seizures
Title: Neuropilin-2 is overexpressed in the rat brain after limbic seizures.

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General gene information

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Markers

D9Got64 (e-PCR)
- UniSTS:116009

BE097230 (e-PCR)
- UniSTS:244622

Nrp2 (e-PCR), detects polymorphism
- UniSTS:531350

BF397549 (e-PCR)
- UniSTS:246223

BF396291 (e-PCR)
- UniSTS:245721

BF406209 (e-PCR)
- UniSTS:248311

Homology

Homologs of the Nrp2 gene: The Nrp2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 486 organisms have orthologs with human gene Nrp2
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in dorsal root ganglion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in facial nerve structural organization	ISO Inferred from Sequence Orthology more info
involved_in facioacoustic ganglion development	ISO Inferred from Sequence Orthology more info
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in nerve development	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration involved in autonomic nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance	ISO Inferred from Sequence Orthology more info
involved_in sensory neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in sympathetic ganglion development	ISO Inferred from Sequence Orthology more info
involved_in sympathetic neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in sympathetic neuron projection guidance	ISO Inferred from Sequence Orthology more info
involved_in trigeminal ganglion development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trunk neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ventral trunk neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve structural organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropilin-2

Names: vascular endothelial cell growth factor 165 receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030869.4 → NP_110496.1 neuropilin-2 precursor

See identical proteins and their annotated locations for NP_110496.1

Status: PROVISIONAL

Source sequence(s)

JACYVU010000214

UniProtKB/Swiss-Prot

O35276

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:846 → 922

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

NC_051344.1 Reference mRatBN7.2 Primary Assembly

Range

64122815..64238007

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245039.4 → XP_006245101.1 neuropilin-2 isoform X1

UniProtKB/TrEMBL

A0A8I6AF12

Related

ENSRNOP00000090812.1, ENSRNOT00000105009.1

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:851 → 927

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_008767137.3 → XP_008765359.1 neuropilin-2 isoform X2

UniProtKB/TrEMBL

A0A8L2UM12

Related

ENSRNOP00000047206.3, ENSRNOT00000042562.4

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:834 → 910

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006245041.4 → XP_006245103.1 neuropilin-2 isoform X4

UniProtKB/TrEMBL

A0A8I6AH16

Related

ENSRNOP00000094102.1, ENSRNOT00000119267.1

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:822 → 901

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006245042.4 → XP_006245104.1 neuropilin-2 isoform X5

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:817 → 896

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006245040.4 → XP_006245102.1 neuropilin-2 isoform X3

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:829 → 905

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_039084243.1 → XP_038940171.1 neuropilin-2 isoform X6

Conserved Domains (3) summary

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.