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Nrp2 neuropilin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81527, updated on 30-Sep-2021

Summary

Official Symbol
Nrp2provided by RGD
Official Full Name
neuropilin 2provided by RGD
Primary source
RGD:621442
See related
EnsemblRapid:ENSRNOG00000031232
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
an axonal guidance molecule [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 127.6), Heart (RPKM 80.7) and 9 other tissues See more
Orthologs
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Genomic context

See Nrp2 in Genome Data Viewer
Location:
9q32
Exon count:
19
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (64122815..64238007)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (69496875..69609802)

Chromosome 9 - NC_051344.1Genomic Context describing neighboring genes Neighboring gene similar to Multifunctional protein ADE2 Neighboring gene par-3 family cell polarity regulator beta Neighboring gene uncharacterized LOC102548410 Neighboring gene ribosomal protein L37-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables semaphorin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in axon guidance IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal root ganglion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in facial nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
involved_in facioacoustic ganglion development ISO
Inferred from Sequence Orthology
more info
 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neural crest cell migration involved in autonomic nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic ganglion development ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic neuron projection guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in trigeminal ganglion development ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ventral trunk neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in vestibulocochlear nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuropilin-2
Names
vascular endothelial cell growth factor 165 receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030869.4NP_110496.1  neuropilin-2 precursor

    See identical proteins and their annotated locations for NP_110496.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000214
    UniProtKB/Swiss-Prot
    O35276
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:846922
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051344.1 Reference mRatBN7.2 Primary Assembly

    Range
    64122815..64238007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245039.4XP_006245101.1  neuropilin-2 isoform X1

    Related
    ENSRNOP00000090812.1, ENSRNOT00000105009.1
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:851927
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_008767137.3XP_008765359.1  neuropilin-2 isoform X2

    Related
    ENSRNOP00000047206.3, ENSRNOT00000042562.4
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:834910
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_006245041.4XP_006245103.1  neuropilin-2 isoform X4

    Related
    ENSRNOP00000094102.1, ENSRNOT00000119267.1
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:822901
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. XM_006245042.4XP_006245104.1  neuropilin-2 isoform X5

    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:817896
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. XM_006245040.4XP_006245102.1  neuropilin-2 isoform X3

    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:829905
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. XM_039084243.1XP_038940171.1  neuropilin-2 isoform X6

    Conserved Domains (3) summary
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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