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Mdk midkine [ Rattus norvegicus (Norway rat) ]

Gene ID: 81517, updated on 18-Apr-2019

Summary

Official Symbol
Mdkprovided by RGD
Official Full Name
midkineprovided by RGD
Primary source
RGD:69073
See related
Ensembl:ENSRNOG00000017560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
heparin-binding growth factor; involved in early fetal development of the rat adrenal [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 131.7), Lung (RPKM 67.0) and 9 other tissues See more
Orthologs

Genomic context

See Mdk in Genome Data Viewer
Location:
3q24
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80841003..80843895, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (87539671..87542415, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene harbinger transposase derived 1 Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene ATP synthase lipid-binding protein, mitochondrial-like Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene uncharacterized LOC103691847 Neighboring gene diacylglycerol kinase zeta Neighboring gene cAMP responsive element binding protein 3-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparan sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
T cell activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
adrenal gland development IDA
Inferred from Direct Assay
more info
PubMed 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response ISO
Inferred from Sequence Orthology
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cerebellar granular layer development IEA
Inferred from Electronic Annotation
more info
 
cerebellar granular layer development ISO
Inferred from Sequence Orthology
more info
PubMed 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
defecation IEA
Inferred from Electronic Annotation
more info
 
defecation ISO
Inferred from Sequence Orthology
more info
PubMed 
dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
dentate gyrus development ISO
Inferred from Sequence Orthology
more info
PubMed 
estrous cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
glial cell projection elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
PubMed 
leukocyte chemotaxis involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of regulatory T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation blood vessel branching ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hepatocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-12 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of keratinocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of leukocyte adhesion to vascular endothelial cell ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of leukocyte cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of leukocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neutrophil extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of vascular endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to auditory stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
PubMed 
short-term memory IEA
Inferred from Electronic Annotation
more info
 
short-term memory ISO
Inferred from Sequence Orthology
more info
PubMed 
tissue regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030859.2NP_110486.1  midkine precursor

    See identical proteins and their annotated locations for NP_110486.1

    Status: PROVISIONAL

    Source sequence(s)
    AB025023
    UniProtKB/Swiss-Prot
    Q9R1S9
    UniProtKB/TrEMBL
    A9UMV0
    Conserved Domains (1) summary
    smart00193
    Location:34113
    PTN; Pleiotrophin / midkine family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    80841003..80843895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234593.3XP_006234655.1  midkine isoform X2

    See identical proteins and their annotated locations for XP_006234655.1

    UniProtKB/Swiss-Prot
    Q9R1S9
    UniProtKB/TrEMBL
    A9UMV0
    Conserved Domains (1) summary
    smart00193
    Location:34113
    PTN; Pleiotrophin / midkine family
  2. XM_006234592.2XP_006234654.1  midkine isoform X2

    See identical proteins and their annotated locations for XP_006234654.1

    UniProtKB/Swiss-Prot
    Q9R1S9
    UniProtKB/TrEMBL
    A9UMV0
    Related
    ENSRNOP00000036207.3, ENSRNOT00000033978.3
    Conserved Domains (1) summary
    smart00193
    Location:34113
    PTN; Pleiotrophin / midkine family
  3. XM_006234591.3XP_006234653.1  midkine isoform X1

    Conserved Domains (1) summary
    smart00193
    Location:36115
    PTN; Pleiotrophin / midkine family

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    77104074..77105431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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