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Lrrn3 leucine rich repeat neuronal 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81514, updated on 5-Feb-2026
Official Symbol
Lrrn3provided by RGD
Official Full Name
leucine rich repeat neuronal 3provided by RGD
Primary source
RGD:71066
See related
Ensembl:ENSRNOG00000006368 AllianceGenome:RGD:71066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nlrr3
Summary
Involved in positive regulation of protein phosphorylation. Part of clathrin adaptor complex. Orthologous to human LRRN3 (leucine rich repeat neuronal 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Brain (RPKM 201.3), Lung (RPKM 113.2) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Lrrn3 in Genome Data Viewer
Location:
6q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (64216164..64247293, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (58489060..58520322, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (61374328..61405195, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene inner mitochondrial membrane peptidase subunit 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120093203 Neighboring gene uncharacterized LOC134479121 Neighboring gene uncharacterized LOC120103525

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. [Role of LRRN3 in the cerebellum postnatal development in rats]. Yang J, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011 May. PMID 21685698
  2. Mapping the microtubule binding regions of calponin. Fattoum A, et al. Biochemistry, 2003 Feb 11. PMID 12564930
  3. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. Fukamachi K, et al. J Biol Chem, 2002 Nov 15. PMID 12297494
  4. Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. Fukamachi K, et al. Biochem Biophys Res Commun, 2001 Sep 14. PMID 11549284
  5. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Herlan L, et al. Clin Exp Pharmacol Physiol, 2015 Oct. PMID 26192016

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRRN3 plays an important role in postnatal cerebellum development.
    Title: [Role of LRRN3 in the cerebellum postnatal development in rats].
  2. NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles
    Title: Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs.
  3. rNLRR-3 gene expression is regulated mainly through the Ras-MAPK signaling pathway in fibroblasts
    Title: Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of clathrin adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
leucine-rich repeat neuronal protein 3
Names
NLRR-3
leucine rich repeat protein 3, neuronal
neuronal leucine-rich repeat protein 3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030856.2 → NP_110483.2  leucine-rich repeat neuronal protein 3 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q642E4, Q9ESY6
    UniProtKB/TrEMBL
    A0A0G2JSI7, A6HBE1
    Conserved Domains (8) summary
    TIGR00864
    Location:341 → 405
    PCC; polycystin cation channel protein
    smart00013
    Location:28 → 72
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:72 → 355
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:336 → 359
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:94 → 117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:526 → 593
    fn3; Fibronectin type III domain
    cd00096
    Location:440 → 447
    Ig; Ig strand B [structural motif]
    cl11960
    Location:440 → 513
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    64216164..64247293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262547.1 → XP_063118617.1  leucine-rich repeat neuronal protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q642E4, Q9ESY6
    UniProtKB/TrEMBL
    A0A0G2JSI7, A6HBE1
    Related
    ENSRNOP00000008655.1, ENSRNOT00000008655.4

  2. XM_063262546.1 → XP_063118616.1  leucine-rich repeat neuronal protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q642E4, Q9ESY6
    UniProtKB/TrEMBL
    A0A0G2JSI7, A6HBE1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESY6.1 GenPept UniProtKB/Swiss-Prot:Q9ESY6

Gene LinkOut

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