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Grb2 growth factor receptor bound protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81504, updated on 10-Oct-2019

Summary

Official Symbol
Grb2provided by RGD
Official Full Name
growth factor receptor bound protein 2provided by RGD
Primary source
RGD:619758
See related
Ensembl:ENSRNOG00000003990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ash-psi
Summary
acts as a link between tyrosine kinase receptors and Ras signaling [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 244.2), Brain (RPKM 239.6) and 9 other tissues See more
Orthologs

Genomic context

See Grb2 in Genome Data Viewer
Location:
10q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104193953..104263071, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (104019823..104087251) , (104735560..104738091, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19 Neighboring gene developmental pluripotency-associated protein 2-like Neighboring gene microRNA 3577

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC108668

Gene Ontology Provided by RGD

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
SH3/SH2 adaptor activity IEA
Inferred from Electronic Annotation
more info
 
SH3/SH2 adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
epidermal growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
PubMed 
neurotrophin TRKA receptor binding IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
aging IPI
Inferred from Physical Interaction
more info
PubMed 
anatomical structure formation involved in morphogenesis IEA
Inferred from Electronic Annotation
more info
 
anatomical structure formation involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in labyrinthine layer morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IEA
Inferred from Electronic Annotation
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
signal transduction in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
COP9 signalosome ISO
Inferred from Sequence Orthology
more info
PubMed 
COP9 signalosome ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Grb2-EGFR complex IEA
Inferred from Electronic Annotation
more info
 
Grb2-EGFR complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
vesicle membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
growth factor receptor-bound protein 2
Names
SH2/SH3 adapter GRB2
adapter protein GRB2
protein Ash

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030846.2NP_110473.2  growth factor receptor-bound protein 2

    See identical proteins and their annotated locations for NP_110473.2

    Status: VALIDATED

    Source sequence(s)
    AA926364, BC091144
    UniProtKB/Swiss-Prot
    P62994
    Related
    ENSRNOP00000005347.4, ENSRNOT00000005347.5
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    104193953..104263071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    99455840..99524352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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