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Sil1 SIL1 nucleotide exchange factor [ Mus musculus (house mouse) ]

Gene ID: 81500, updated on 8-Dec-2022

Summary

Official Symbol
Sil1provided by MGI
Official Full Name
SIL1 nucleotide exchange factorprovided by MGI
Primary source
MGI:MGI:1932040
See related
Ensembl:ENSMUSG00000024357 AllianceGenome:MGI:1932040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wz; 1810057E01Rik
Summary
Predicted to enable adenyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to act upstream of or within protein transport. Located in endoplasmic reticulum. Is expressed in brain; chondrocranium; eye; pancreas; and testis. Human ortholog(s) of this gene implicated in primary cerebellar degeneration. Orthologous to human SIL1 (SIL1 nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 27.6), adrenal adult (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Sil1 in Genome Data Viewer
Location:
18; 18 B1- B2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35399449..35632443, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35266396..35499390, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46617 Neighboring gene catenin (cadherin associated protein), alpha 1 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC118568353 Neighboring gene predicted gene, 41691 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleotide exchange factor SIL1
Names
endoplasmic reticulum chaperone SIL1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360814.1NP_001347743.1  nucleotide exchange factor SIL1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC121874, AC147989, AC153145
    Consensus CDS
    CCDS29140.1
    UniProtKB/Swiss-Prot
    Q91V34
    UniProtKB/TrEMBL
    A0A8C6MTJ1
    Conserved Domains (1) summary
    pfam08609
    Location:196226
    Fes1; Nucleotide exchange factor Fes1
  2. NM_030749.2NP_109674.2  nucleotide exchange factor SIL1 precursor

    See identical proteins and their annotated locations for NP_109674.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BP771607, BX512650, CO428760, CX219879
    Consensus CDS
    CCDS29140.1
    UniProtKB/Swiss-Prot
    Q91V34, Q9EPK6
    UniProtKB/TrEMBL
    A0A8C6MTJ1
    Related
    ENSMUSP00000025215.9, ENSMUST00000025215.10
    Conserved Domains (1) summary
    pfam08609
    Location:196226
    Fes1; Nucleotide exchange factor Fes1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35399449..35632443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250634.1XP_030106494.1  nucleotide exchange factor SIL1 isoform X1

    UniProtKB/Swiss-Prot
    Q91V34
    UniProtKB/TrEMBL
    A0A8C6MTJ1
  2. XM_036161310.1XP_036017203.1  nucleotide exchange factor SIL1 isoform X1

    UniProtKB/Swiss-Prot
    Q91V34
    UniProtKB/TrEMBL
    A0A8C6MTJ1
  3. XM_011247043.3XP_011245345.1  nucleotide exchange factor SIL1 isoform X1

    See identical proteins and their annotated locations for XP_011245345.1

    UniProtKB/Swiss-Prot
    Q91V34, Q9EPK6
    UniProtKB/TrEMBL
    A0A8C6MTJ1
    Conserved Domains (1) summary
    pfam08609
    Location:196226
    Fes1; Nucleotide exchange factor Fes1
  4. XM_006526365.4XP_006526428.1  nucleotide exchange factor SIL1 isoform X1

    See identical proteins and their annotated locations for XP_006526428.1

    UniProtKB/Swiss-Prot
    Q91V34, Q9EPK6
    UniProtKB/TrEMBL
    A0A8C6MTJ1
    Conserved Domains (1) summary
    pfam08609
    Location:196226
    Fes1; Nucleotide exchange factor Fes1
  5. XM_030250635.1XP_030106495.1  nucleotide exchange factor SIL1 isoform X2

  6. XM_006526367.5XP_006526430.1  nucleotide exchange factor SIL1 isoform X3

    Conserved Domains (1) summary
    pfam08609
    Location:197226
    Fes1; Nucleotide exchange factor Fes1