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CAMK2A calcium/calmodulin dependent protein kinase II alpha [ Homo sapiens (human) ]

Gene ID: 815, updated on 9-Feb-2020

Summary

Official Symbol
CAMK2Aprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II alphaprovided by HGNC
Primary source
HGNC:HGNC:1460
See related
Ensembl:ENSG00000070808 MIM:114078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKA; MRD53; MRT63; CaMKIIalpha; CaMKIINalpha
Summary
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]
Expression
Restricted expression toward brain (RPKM 112.2) See more
Orthologs

Genomic context

See CAMK2A in Genome Data Viewer
Location:
5q32
Exon count:
20
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (150219491..150290130, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149599054..149669403, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene caudal type homeobox 1 Neighboring gene solute carrier family 6 member 7 Neighboring gene arylsulfatase family member I Neighboring gene Sharpr-MPRA regulatory region 14436

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
MENTAL RETARDATION, AUTOSOMAL DOMINANT 53
MedGen: C4540481 OMIM: 617798 GeneReviews: Not available
Compare labs
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 63
MedGen: C4748167 OMIM: 618095 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2019-09-04)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2019-09-04)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces upregulation of HDAC2 expression and downregulation of CREB and CaMKIIa expression in human neuroblastoma SK-N-MC cells PubMed
tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0968

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of mitochondrial membrane permeability involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
Names
CaM kinase II alpha subunit
CaM-kinase II alpha chain
CaMK-II alpha subunit
caM kinase II subunit alpha
caMK-II subunit alpha
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
calcium/calmodulin-dependent protein kinase II alpha-B subunit
calcium/calmodulin-dependent protein kinase type II alpha chain
NP_001350918.1
NP_001350919.1
NP_001355954.1
NP_057065.2
NP_741960.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047040.1 RefSeqGene

    Range
    5068..75350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363989.1NP_001350918.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011372
    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001363990.1NP_001350919.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011372
    Related
    ENSP00000500642.1, ENST00000672479.1
    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_001369025.2NP_001355954.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011372
    Related
    ENSP00000499939.1, ENST00000672752.1
    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. NM_015981.4NP_057065.2  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_057065.2

    Status: REVIEWED

    Source sequence(s)
    AC011372, AK289776, BC040457, BF951952
    Consensus CDS
    CCDS43387.1
    UniProtKB/TrEMBL
    A8K161, Q8IWE0
    Related
    ENSP00000500386.1, ENST00000671881.1
    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. NM_171825.2NP_741960.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_741960.1

    Status: REVIEWED

    Source sequence(s)
    AB023185, AC011372, AK289776, BC040457, BF951952
    Consensus CDS
    CCDS43386.1
    UniProtKB/Swiss-Prot
    Q9UQM7
    UniProtKB/TrEMBL
    A8K161, Q7LDD5, Q8IWE0
    Related
    ENSP00000261793.8, ENST00000348628.10
    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    150219491..150290130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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