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POLR2M RNA polymerase II subunit M [ Homo sapiens (human) ]

Gene ID: 81488, updated on 1-Aug-2020

Summary

Official Symbol
POLR2Mprovided by HGNC
Official Full Name
RNA polymerase II subunit Mprovided by HGNC
Primary source
HGNC:HGNC:14862
See related
Ensembl:ENSG00000255529 MIM:606485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCOM1; Gdown; Gdown1; GRINL1A
Summary
This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]
Expression
Ubiquitous expression in endometrium (RPKM 23.6), ovary (RPKM 17.1) and 25 other tissues See more
Orthologs

Genomic context

See POLR2M in Genome Data Viewer
Location:
15q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (57706521..57717557)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (57998901..58009753)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13 pseudogene 7 Neighboring gene myocardial zonula adherens protein Neighboring gene GRINL1A complex locus 1 Neighboring gene uncharacterized LOC105370834 Neighboring gene uncharacterized LOC107984724

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequent HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough GCOM1

Readthrough gene: GCOM1, Included gene: MYZAP

Homology

Clone Names

  • DKFZp586F1918

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of ER location IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of ER location IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II, core complex IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II, holoenzyme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II, holoenzyme IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein GRINL1A
Names
DNA-directed RNA polymerase II subunit M, isoforms 4/5
GRINL1A downstream protein Gdown4
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
polymerase (RNA) II (DNA directed) polypeptide M
polymerase (RNA) II subunit M
protein GRINL1A, isoforms 4/5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029676.1 RefSeqGene

    Range
    5012..15855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018102.2NP_001018112.1  protein GRINL1A isoform 2

    See identical proteins and their annotated locations for NP_001018112.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Gdown6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090651, AK128618, AL050091, AY339380, BF939412
    Consensus CDS
    CCDS42045.1
    UniProtKB/Swiss-Prot
    P0CAP1, P0CAP2, Q6EEV4
    Related
    ENSP00000369930.4, ENST00000380557.4
    Conserved Domains (1) summary
    pfam15328
    Location:3484
    GCOM2; Putative GRINL1B complex locus protein 2
  2. NM_015532.5NP_056347.1  protein GRINL1A isoform 1

    See identical proteins and their annotated locations for NP_056347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074955, AL050091, AY339380, BF939412
    Consensus CDS
    CCDS32252.1
    UniProtKB/Swiss-Prot
    P0CAP2, Q6EEV4
    Related
    ENSP00000299638.3, ENST00000299638.8
    Conserved Domains (1) summary
    pfam15328
    Location:27241
    GCOM2; Putative GRINL1B complex locus protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    57706521..57717557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_027390.1: Suppressed sequence

    Description
    NR_027390.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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