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TAF15 TATA-box binding protein associated factor 15 [ Homo sapiens (human) ]

Gene ID: 8148, updated on 6-Sep-2021

Summary

Official Symbol
TAF15provided by HGNC
Official Full Name
TATA-box binding protein associated factor 15provided by HGNC
Primary source
HGNC:HGNC:11547
See related
Ensembl:ENSG00000270647 MIM:601574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Npl3; RBP56; TAF2N; TAFII68
Summary
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in testis (RPKM 46.3), lymph node (RPKM 45.2) and 25 other tissues See more
Orthologs
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Genomic context

See TAF15 in Genome Data Viewer
Location:
17q12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (35809484..35847242)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34136488..34174246)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene growth arrest specific 2 like 2 Neighboring gene uncharacterized LOC107985067 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28 Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene HEAT repeat containing 9 Neighboring gene uncharacterized LOC105371744 Neighboring gene C-C motif chemokine ligand 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (TAF15) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TATA-binding protein-associated factor 2N
Names
RBP56/CSMF fusion
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
TATA box-binding protein-associated factor 2N (RNA-binding protein 56)
TBP-associated factor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023279.1 RefSeqGene

    Range
    5001..42759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003487.4NP_003478.1  TATA-binding protein-associated factor 2N isoform 2

    See identical proteins and their annotated locations for NP_003478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1, that results in a shorter protein (isoform 2).
    Source sequence(s)
    AI351964, AK313223, BC039129, DB166653
    Consensus CDS
    CCDS59279.1
    UniProtKB/Swiss-Prot
    Q92804
    Related
    ENSP00000474609.1, ENST00000604841.5
    Conserved Domains (4) summary
    COG0724
    Location:219316
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12535
    Location:229314
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    sd00025
    Location:355376
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:351381
    zf-RanBP; Zn-finger in Ran binding protein and others
  2. NM_139215.3NP_631961.1  TATA-binding protein-associated factor 2N isoform 1

    See identical proteins and their annotated locations for NP_631961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI351964, AK314194, BC046099, BG403710
    Consensus CDS
    CCDS32623.1
    UniProtKB/Swiss-Prot
    Q92804
    Related
    ENSP00000474096.1, ENST00000605844.6
    Conserved Domains (5) summary
    cd12535
    Location:232317
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    sd00025
    Location:358379
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:354384
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam15991
    Location:1124
    G_path_suppress; G-protein pathway suppressor
    cl25887
    Location:136315
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    35809484..35847242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450959.1XP_024306727.1  TATA-binding protein-associated factor 2N isoform X1

    Conserved Domains (3) summary
    sd00025
    Location:89110
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:85115
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl17169
    Location:148
    RRM_SF; RNA recognition motif (RRM) superfamily

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    44016..81774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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