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PF3D7_1360800 falcilysin [ Plasmodium falciparum 3D7 ]

Gene ID: 814283, updated on 15-Feb-2026
Gene symbol
PF3D7_1360800
Gene description
falcilysin
Locus tag
PF3D7_1360800
See related
PlasmoDB:PF3D7_1360800; VEuPathDB:PF3D7_1360800
Gene type
protein coding
RNA name
falcilysin
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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See PF3D7_1360800 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
1
Sequence:
Chromosome: 13; NC_004331.3 (2435343..2438924)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene guanylyl cyclase beta Neighboring gene E3 SUMO-protein ligase PIAS, putative Neighboring gene RNA-binding protein, putative Neighboring gene protein arginine N-methyltransferase 5, putative

Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast. Ponpuak M, et al. Mol Microbiol, 2007 Jan. PMID 17074076
  2. Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum. Eggleson KK, et al. J Biol Chem, 1999 Nov 5. PMID 10542284
  3. Transcript and protein expression analysis of proteases in the blood stages of Plasmodium falciparum. Weißbach T, et al. Exp Parasitol, 2017 Sep. PMID 28351685
  4. Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. Boucher MJ, et al. PLoS Biol, 2018 Sep. PMID 30212465, Free PMC Article
  5. The Plasmodium falciparum histone methyltransferase SET10 participates in a chromatin modulation network crucial for intraerythrocytic development. Musabyimana J-P, et al. mSphere, 2024 Nov 21. PMID 39445823, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables metalloendopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hemoglobin catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apicoplast HDA PubMed 
located_in apicoplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in food vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
falcilysin
XP_001350319.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    2435343..2438924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350283.1 → XP_001350319.1  falcilysin [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350319.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q76NL8, Q9U7N7
    UniProtKB/TrEMBL
    A0A024W1S3, A0A024WKJ0, A0A024X3M5, W4J183, W7F2B7, W7JPE5
    Conserved Domains (1) summary
    PTZ00432
    Location:4 → 1193
    PTZ00432; falcilysin; Provisional
Nucleotide Protein
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