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PF3D7_1335900 thrombospondin-related anonymous protein [ Plasmodium falciparum 3D7 ]

Gene ID: 814170, updated on 25-Jan-2024

Summary

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Gene symbol
PF3D7_1335900
Gene description
thrombospondin-related anonymous protein
Locus tag
PF3D7_1335900
Gene type
protein coding
RNA name
thrombospondin-related anonymous protein
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 13
Exon count:
1
Sequence:
Chromosome: 13; NC_004331.3 (1464895..1466619, complement)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved oligomeric Golgi complex subunit 3, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Population genetic structure analysis of thrombospondin-related adhesive protein (TRAP) as a vaccine candidate antigen in worldwide Plasmodium falciparum isolates. Mehrizi AA, et al. Infect Genet Evol, 2020 Jun. PMID 31954917
  2. Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand. Ohashi J, et al. PLoS One, 2014. PMID 24587387, Free PMC Article
  3. TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites. Sultan AA, et al. Cell, 1997 Aug 8. PMID 9267031
  4. Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum: expression during sporozoite ontogeny and binding to human hepatocytes. Robson KJ, et al. EMBO J, 1995 Aug 15. PMID 7664729, Free PMC Article
  5. Characterization of Plasmodium falciparum sporozoite surface protein 2. Rogers WO, et al. Proc Natl Acad Sci U S A, 1992 Oct 1. PMID 1409621, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Platelet derived growth factor receptor beta (PDGFRbeta) is a host receptor for the human malaria parasite adhesin TRAP.
    Title: Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP.
  2. Population genetic structure analysis of thrombospondin-related adhesive protein (TRAP) as a vaccine candidate antigen in worldwide Plasmodium falciparum isolates.
    Title: Population genetic structure analysis of thrombospondin-related adhesive protein (TRAP) as a vaccine candidate antigen in worldwide Plasmodium falciparum isolates.
  3. The identification of the integrin alphavbeta3 as the host receptor for TRAP provides an important demonstration of a sporozoite surface ligand that directly interacts with host receptors.
    Title: Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP.
  4. The circumsporozoite protein (CSP) and the thrombospondin-related anonymous protein (TRAP) bind to the heparan sulfate proteoglycan on the hepatocyte surface and contribute to sporozoite infection and hepatocyte selectivity.
    Title: Malaria sporozoite protein expression enhances baculovirus-mediated gene transfer to hepatocytes.
  5. The molecular flexibility and the multimeric nature of aldolase are both critical for its interactions with both TRAP and actin in the invasion machinery
    Title: Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
  6. Used a large compound library to study candidate compounds that stabilize and prevent the disassembly of the PfAldolase-TRAP complex of the glideosome.
    Title: Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
  7. Results suggest that the thrombospondin-related adhesive protein (TRAP) molecule is a major target of the human immune response to pre-erythrocytic stages.
    Title: Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand.
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General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables host cell surface receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell gliding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within symbiont entry into host IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within symbiont entry into host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microneme IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thrombospondin-related anonymous protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    1464895..1466619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350052.1 → XP_001350088.1  thrombospondin-related anonymous protein [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350088.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5Q2EZD7, Q26020, Q76NM2, W7K193
    Conserved Domains (1) summary
    PTZ00441
    Location:1 → 574
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
Nucleotide Protein
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Molecular Biology Databases
Research Materials