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SLC7A5 solute carrier family 7 member 5 [ Homo sapiens (human) ]

Gene ID: 8140, updated on 6-Apr-2021

Summary

Official Symbol
SLC7A5provided by HGNC
Official Full Name
solute carrier family 7 member 5provided by HGNC
Primary source
HGNC:HGNC:11063
See related
Ensembl:ENSG00000103257 MIM:600182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E16; CD98; LAT1; 4F2LC; MPE16; D16S469E
Expression
Broad expression in testis (RPKM 35.6), bone marrow (RPKM 34.4) and 17 other tissues See more
Orthologs
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Genomic context

See SLC7A5 in Genome Data Viewer
Location:
16q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (87830022..87869507, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87863629..87903113, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene junctophilin 3 Neighboring gene uncharacterized LOC100129215 Neighboring gene kelch domain containing 4 Neighboring gene uncharacterized LOC105371399 Neighboring gene uncharacterized LOC102724467 Neighboring gene Sharpr-MPRA regulatory region 10585 Neighboring gene uncharacterized LOC107987237 Neighboring gene microRNA 6775 Neighboring gene CRISPRi-validated cis-regulatory element chr16.4806 Neighboring gene microRNA 11401 Neighboring gene carbonic anhydrase 5A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC7A5 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env The functional interaction between CD98 and CD147 is involved in the regulation of HIV-1 gp160-mediated cell fusion PubMed
env Antibodies raised against the human fusion regulatory protein 1 (FRP-1; CD98) molecule suppress cell fusion mediated by HIV-1 gp160 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
L-alpha-amino acid transmembrane transport TAS
Traceable Author Statement
more info
 
L-leucine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
L-leucine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
L-tryptophan transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
amino acid import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
amino acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
amino acid import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leucine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
leucine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
phenylalanine transport IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cytokine production involved in immune response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid hormone transport IDA
Inferred from Direct Assay
more info
PubMed 
transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
amino acid transport complex IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
external side of apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
large neutral amino acids transporter small subunit 1
Names
4F2 light chain
CD98 light chain
L-type amino acid transporter 1
integral membrane protein E16
sodium-independent neutral amino acid transporter LAT1
solute carrier family 7 (amino acid transporter light chain, L system), member 5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003486.7NP_003477.4  large neutral amino acids transporter small subunit 1

    See identical proteins and their annotated locations for NP_003477.4

    Status: VALIDATED

    Source sequence(s)
    AC126696, AF104032
    Consensus CDS
    CCDS10964.1
    UniProtKB/Swiss-Prot
    Q01650
    Related
    ENSP00000261622.4, ENST00000261622.5
    Conserved Domains (1) summary
    TIGR00911
    Location:26506
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    87830022..87869507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721286.3XP_006721349.2  large neutral amino acids transporter small subunit 1 isoform X3

  2. XM_017023736.1XP_016879225.1  large neutral amino acids transporter small subunit 1 isoform X2

  3. XM_017023735.1XP_016879224.1  large neutral amino acids transporter small subunit 1 isoform X1

  4. XM_017023737.2XP_016879226.1  large neutral amino acids transporter small subunit 1 isoform X4

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