Format

Send to:

Choose Destination

SLC7A5 solute carrier family 7 member 5 [ Homo sapiens (human) ]

Gene ID: 8140, updated on 17-Sep-2017
Official Symbol
SLC7A5provided by HGNC
Official Full Name
solute carrier family 7 member 5provided by HGNC
Primary source
HGNC:HGNC:11063
See related
Ensembl:ENSG00000103257 MIM:600182; Vega:OTTHUMG00000137658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E16; CD98; LAT1; 4F2LC; MPE16; D16S469E
Orthologs
Location:
16q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (87830022..87869499, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87863629..87903100, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371397 Neighboring gene kelch domain containing 4 Neighboring gene uncharacterized LOC105371399 Neighboring gene uncharacterized LOC102724467 Neighboring gene microRNA 6775 Neighboring gene uncharacterized LOC107987237 Neighboring gene uncharacterized LOC105371400 Neighboring gene carbonic anhydrase 5A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC7A5 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env The functional interaction between CD98 and CD147 is involved in the regulation of HIV-1 gp160-mediated cell fusion PubMed
env Antibodies raised against the human fusion regulatory protein 1 (FRP-1; CD98) molecule suppress cell fusion mediated by HIV-1 gp160 PubMed

Go to the HIV-1, Human Interaction Database

  • Amino acid transport across the plasma membrane, organism-specific biosystem (from REACTOME)
    Amino acid transport across the plasma membrane, organism-specific biosystemAmino acid transport across plasma membranes is critical to the uptake of these molecules from the gut, to their reabsortion in the kidney proximal tubulues, and to their distribution to cells in whi...
  • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
  • Basigin interactions, organism-specific biosystem (from REACTOME)
    Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Central carbon metabolism in cancer, organism-specific biosystem (from KEGG)
    Central carbon metabolism in cancer, organism-specific biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Central carbon metabolism in cancer, conserved biosystem (from KEGG)
    Central carbon metabolism in cancer, conserved biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, organism-specific biosystem (from REACTOME)
    Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, organism-specific biosystemThe catabolic pathways of histidine, lysine, phenylalanine, tyrosine, proline and tryptophan are described in this section (Berg et al. 2002).
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
    Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...
  • Tryptophan catabolism, organism-specific biosystem (from REACTOME)
    Tryptophan catabolism, organism-specific biosystemTryptophan is catabolized in seven steps to yield aminomuconate. Intermedistes in this process are used as well for the synthesis of serotonin and kynurenine (Peters 1991).
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
neutral amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
peptide antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-alpha-amino acid transmembrane transport TAS
Traceable Author Statement
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular amino acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
large neutral amino acids transporter small subunit 1
Names
4F2 light chain
CD98 light chain
L-type amino acid transporter 1
integral membrane protein E16
sodium-independent neutral amino acid transporter LAT1
solute carrier family 7 (amino acid transporter light chain, L system), member 5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003486.6NP_003477.4  large neutral amino acids transporter small subunit 1

    See identical proteins and their annotated locations for NP_003477.4

    Status: VALIDATED

    Source sequence(s)
    AC126696, AF104032, AW090427
    Consensus CDS
    CCDS10964.1
    UniProtKB/Swiss-Prot
    Q01650
    Related
    ENSP00000261622.4, OTTHUMP00000175013, ENST00000261622.4, OTTHUMT00000269110
    Conserved Domains (1) summary
    TIGR00911
    Location:26506
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

    Range
    87830022..87869499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721286.3XP_006721349.2  large neutral amino acids transporter small subunit 1 isoform X3

  2. XM_017023736.1XP_016879225.1  large neutral amino acids transporter small subunit 1 isoform X2

  3. XM_017023735.1XP_016879224.1  large neutral amino acids transporter small subunit 1 isoform X1

  4. XM_017023737.1XP_016879226.1  large neutral amino acids transporter small subunit 1 isoform X4

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    89274981..89314543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center