Format

Send to:

Choose Destination

CAMK4 calcium/calmodulin dependent protein kinase IV [ Homo sapiens (human) ]

Gene ID: 814, updated on 13-Dec-2020

Summary

Official Symbol
CAMK4provided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase IVprovided by HGNC
Primary source
HGNC:HGNC:1464
See related
Ensembl:ENSG00000152495 MIM:114080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
caMK; CaMKIV; CaMK IV; CaMK-GR
Summary
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 7.0), lymph node (RPKM 3.7) and 21 other tissues See more
Orthologs
NEW
Try the new Data Table view

Genomic context

See CAMK4 in Genome Data Viewer
Location:
5q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (111223583..111498503)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (110559947..110830584)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene proline rich nuclear receptor coactivator 2 pseudogene Neighboring gene RPS3A pseudogene 21 Neighboring gene uncharacterized LOC105369177 Neighboring gene STARD4 antisense RNA 1 Neighboring gene StAR related lipid transfer domain containing 4 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.
GeneReviews: Not available
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
GeneReviews: Not available
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
GeneReviews: Not available
Genome-wide association study of chronic periodontitis in a general German population.
GeneReviews: Not available
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36771

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT myeloid dendritic cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of T cell differentiation in thymus TAS
Traceable Author Statement
more info
PubMed 
regulation of osteoclast differentiation TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type IV
Names
CAM kinase IV
CAM kinase- GR
brain Ca(2+)-calmodulin-dependent protein kinase type IV
brain Ca++-calmodulin-dependent protein kinase type IV
calcium/calmodulin-dependent protein kinase type IV catalytic chain
NP_001310303.1
NP_001310304.1
NP_001310305.1
NP_001310306.1
NP_001735.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Data Table view

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323374.2NP_001310303.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010468, AC011422, BQ018740, BX374853, L24959
    Consensus CDS
    CCDS4103.1
    UniProtKB/Swiss-Prot
    Q16566
    Related
    ENSP00000422634.1, ENST00000512453.5
    Conserved Domains (2) summary
    cd14085
    Location:42335
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    pfam00069
    Location:46300
    Pkinase; Protein kinase domain
  2. NM_001323375.2NP_001310304.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010275, AC010468, AC011422, BQ018740
    Consensus CDS
    CCDS4103.1
    UniProtKB/Swiss-Prot
    Q16566
    Conserved Domains (2) summary
    cd14085
    Location:42335
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    pfam00069
    Location:46300
    Pkinase; Protein kinase domain
  3. NM_001323376.2NP_001310305.1  calcium/calmodulin-dependent protein kinase type IV isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011422, AK311662, BQ018740, BX374853
    Conserved Domains (1) summary
    cl21453
    Location:1138
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001323377.2NP_001310306.1  calcium/calmodulin-dependent protein kinase type IV isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010275, AC010468, AC011422, BQ018740
    Conserved Domains (1) summary
    cl21453
    Location:1138
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001744.6NP_001735.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

    See identical proteins and their annotated locations for NP_001735.1

    Status: REVIEWED

    Source sequence(s)
    AC011422, BC025687, BQ018740, DA396146
    Consensus CDS
    CCDS4103.1
    UniProtKB/Swiss-Prot
    Q16566
    Related
    ENSP00000282356.4, ENST00000282356.9
    Conserved Domains (2) summary
    cd14085
    Location:42335
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    pfam00069
    Location:46300
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    111223583..111498503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_948303.2 RNA Sequence

  2. XR_001742281.2 RNA Sequence

  3. XR_001742282.2 RNA Sequence

Support Center