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PF3D7_0923800.1 thioredoxin reductase [ Plasmodium falciparum 3D7 ]

Gene ID: 813514, updated on 18-Aug-2023

Summary

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Gene symbol
PF3D7_0923800.1
Gene description
thioredoxin reductase
Locus tag
PF3D7_0923800.1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Old locus tag
PF3D7_0923800.2
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Genomic context

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Location:
chromosome: 9
Exon count:
1
Sequence:
Chromosome: 9; NC_004330.2 (961933..963786, complement)

Chromosome 9 - NC_004330.2Genomic Context describing neighboring genes Neighboring gene lipoate-protein ligase 2 Neighboring gene conserved protein, unknown function Neighboring gene polyadenylate-binding protein 2, putative Neighboring gene patatin-like phospholipase, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004330.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A "Seleno Effect" Differentiates the Roles of Redox Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase. O'Keefe JP, et al. Biochemistry, 2018 Mar 20. PMID 29485860, Free PMC Article
  2. Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box. Tiwari NK, et al. Molecules, 2016 Mar 28. PMID 27043496, Free PMC Article
  3. Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery. McCarty SE, et al. Molecules, 2015 Jun 22. PMID 26111176, Free PMC Article
  4. Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex. Fritz-Wolf K, et al. J Mol Biol, 2013 Sep 23. PMID 23845423
  5. Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target. Boumis G, et al. Biochem Biophys Res Commun, 2012 Sep 7. PMID 22889878

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A "Seleno Effect" Differentiates the Roles of Redox Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase.
    Title: A "Seleno Effect" Differentiates the Roles of Redox Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase.
  2. Five compounds with significant PfTrxR inhibitory activity, with IC50 values ranging from 0.9-7.5 microM against the target enzyme, were found out of the Malaria Box.
    Title: Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box.
  3. This review paper provides an overview of the structure and function of TrxR, and gives an overview of modeling Plasmodium infections in animals, and suggests the role of Trx functions in antimalarial drug resistance..
    Title: Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery.
  4. Functional analysis of amino acid residues involved in substrate binding and in the architecture of the intersubunit cavity of thioredoxin reductase, which is a known binding site for disulfide reductase inhibitors.
    Title: Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex.
  5. the first crystal structure of recombinant P. falciparum thioredoxin reductase (PfTrxR) at 2.9A was presented.
    Title: Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
thioredoxin reductase
XP_002808951.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004330.2 Reference assembly

    Range
    961933..963786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002808905.1 → XP_002808951.1  thioredoxin reductase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_002808951.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A143ZVU1, P61076, Q71G50
    UniProtKB/TrEMBL
    A0A024VG47, A0A024W7T5, A0A024WSH4, A0A0L1IH40, W7FN69, W7FZL7, W7JXY5
    Conserved Domains (1) summary
    PTZ00052
    Location:113 → 612
    PTZ00052; thioredoxin reductase; Provisional

  2. XM_024473202.1 → XP_024329017.1  thioredoxin reductase [Plasmodium falciparum 3D7]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q25861, Q25864
    UniProtKB/TrEMBL
    A0A0L7K885, A0A0L7M7V3, A0A2I0BT44, W7JYX8
    Conserved Domains (1) summary
    PTZ00052
    Location:37 → 536
    PTZ00052; thioredoxin reductase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61076.2

Gene LinkOut

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